Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study
Serum polyunsaturated fatty acids are not associated with the risk of severe depression in middle-aged Finnish men: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study
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血清多不饱和脂肪酸与芬兰中年男性患严重抑郁症的风险无关：库奥皮奥缺血性心脏病风险因素 (KIHD) 研究
DOI：
10.1007/s00394-010-0118-7
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发表时间：
2011
影响因子：
5
通讯作者：
S. Voutilainen
中科院分区：
文献类型：
--
作者：
A. Ruusunen;J. Virtanen;S. Lehto;T. Tolmunen;J. Kauhanen;S. Voutilainen
PurposeThe目的本研究的目的是调查是否血清n-3多不饱和脂肪酸（PUFAs）或n-6到n-3的比例与中年芬兰男性的严重抑郁症的风险有关。MethodsThe协会之间的血清脂肪酸浓度和抑郁症进行了调查，在2077名男性年龄在42-60岁的基线在一个前瞻性的后续设置。基于人群的库奥皮奥缺血性心脏病风险因素（KIHD）研究队列于1984年至1989年招募，并随访至2007年底。测定血清总n − 3 PUFA、n − 6 PUFA和单个脂肪酸的基线水平。数据来自全国医院出院register.ResultsDuring的平均随访时间为18年，46名男子收到了抑郁症的出院诊断。当考克斯比例风险模型根据年龄、检查年份、基线社会经济状况、饮酒量、吸烟、最大摄氧量和体重指数进行校正时，血清总n − 3 PUFA与抑郁风险之间没有相关性[最高与最低三分位数相比的相对风险（RR）为0.71，95%置信区间（CI）：0.38; 1.43]。血清n-6 PUFA浓度，n6/n3 PUFA比率，或个别脂肪酸与严重抑郁症的风险无关，either.ConclusionsWe没有发现证据表明，血清n-3 PUFA浓度或n-6/n-3比率将与中年芬兰男性严重抑郁症的风险。
PurposeThe aim of this study is to investigate whether serum n − 3 polyunsaturated fatty acids (PUFAs) or n − 6 to n − 3 ratio is associated with risk of severe depression in middle-aged Finnish men.MethodsThe association between the serum concentrations of fatty acids and depression was investigated in 2077 men aged 42–60 years at baseline in a prospective follow-up setting. The population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study cohort was recruited between 1984 and 1989 and followed until the end of 2007. The baseline levels of serum total n − 3 PUFAs, n − 6 PUFAs and individual fatty acids were determined. Data on hospital treatments due to major depressive disorder were derived from the national hospital discharge register.ResultsDuring the average follow-up time of 18 years, 46 men received a discharge diagnosis of depression. When the Cox proportional hazards model was adjusted for age, examination year, baseline socioeconomic status, alcohol consumption, smoking, maximal oxygen uptake and body mass index, there was no association between serum total n − 3 PUFAs and the risk of depression [relative risk (RR) in the highest compared to the lowest tertile 0.71, 95% confidence interval (CI): 0.38; 1.43]. Serum concentrations of n − 6 PUFAs, n6/n3 PUFA ratio, or individual fatty acids were not associated with the risk of severe depression, either.ConclusionsWe did not find evidence that serum n − 3 PUFA concentration or n − 6/n − 3 ratio would be associated with risk of severe depression in middle-aged Finnish men.