BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer
BEX2 is poor prognostic factor and required for cancer stemness in gastric cancer
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DOI：
10.1016/j.bbrc.2023.03.025
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发表时间：
2023-03-16
影响因子：
3.1
通讯作者：
Tamai，Keiichi
中科院分区：
文献类型：
--
作者：
Yasumoto，Akihiro;Fujimori，Haruna;Tamai，Keiichi
胃癌是全球第五大常见恶性肿瘤。然而，晚期胃癌的靶向治疗仍然有限。在这里，我们报告BEX2（脑表达X连锁2）作为一个不良预后因素在两个胃癌队列。BEX2在球状体细胞中的表达增加，其敲低降低了aldefluor活性和顺铂耐药性。发现BEX 2以转录方式上调CHRNB 2（胆碱能受体烟碱β 2亚基）表达，CHRNB 2是一种癌症干细胞相关基因，并且其敲低也降低aldefluor活性。总的来说，这些数据提示BEX 2在胃癌恶性过程中的作用，并作为一个有前途的治疗靶点。
Gastric cancer is the fifth most common malignancy worldwide. However, targeted therapy for advanced gastric cancer is still limited. Here, we report BEX2 (Brain expressed X-linked 2) as a poor prognostic factor in two gastric cancer cohorts. BEX2 expression was increased in spheroid cells, and its knockdown decreased aldefluor activity and cisplatin resistance. BEX2 was found to upregulate CHRNB2 (Cholinergic Receptor Nicotinic Beta 2 Subunit) expression, a cancer stemness-related gene, in a transcriptional manner, and the knockdown of which also decreases aldefluor activity. Collectively, these data are suggestive of the role of BEX2 in the malignant process of gastric cancer, and as a promising therapeutic target.