A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis
A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis
复制标题
DOI：
10.3390/nu12041193
复制
发表时间：
2020-04-01
期刊：
影响因子：
5.9
通讯作者：
Du, Jun
中科院分区：
文献类型：
--
作者：
Chen, Liang;Hu, Chun;Du, Jun
近年来，新型冠状病毒（CoV）在世界范围内周期性出现。冠状病毒的反复传播对全球健康和经济构成持续威胁。由于没有针对这些冠状病毒的具体疗法，因此任何有益的方法（包括营养和饮食方法）都值得研究。基于营养素和植物营养素研究的最新进展，开发了一种维生素 C、姜黄素和甘草酸 (VCG Plus) 的新型组合，具有对抗 CoV 感染的潜力。应用系统生物学工具来探索 VCG Plus 在调节与免疫和炎症反应相关的靶点和途径方面的潜力。连续进行基因靶点获取、基因本体论和京都基因和基因组百科全书（KEGG）通路富集以及网络分析。结果表明，VCG Plus 可作用于 88 个与免疫和炎症反应密切相关的中枢靶点。具体来说，VCG Plus 具有通过作用于 NOD 样和 Toll 样信号通路来调节先天免疫反应的潜力，以促进干扰素产生，激活和平衡 T 细胞，并通过抑制 PI3K/AKT、NF-kappa B 和 MAPK 信号通路来调节炎症反应。所有这些生物过程和途径已在冠状病毒感染研究中得到充分记录。因此，我们的研究结果表明，VCG Plus可能有助于调节免疫反应以对抗冠状病毒感染，并抑制过度的炎症反应以防止细胞因子风暴的发生。然而，需要进一步的体外和体内实验来利用系统生物学工具验证当前的发现。我们目前的方法提供了一种在开发新膳食补充剂时预测配方原理的新策略。
Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The recurrent spreading of CoVs imposes an ongoing threat to global health and the economy. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. Based on recent advances in nutrients and phytonutrients research, a novel combination of vitamin C, curcumin and glycyrrhizic acid (VCG Plus) was developed that has potential against CoV infection. System biology tools were applied to explore the potential of VCG Plus in modulating targets and pathways relevant to immune and inflammation responses. Gene target acquisition, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment were conducted consecutively along with network analysis. The results show that VCG Plus can act on 88 hub targets which are closely connected and associated with immune and inflammatory responses. Specifically, VCG Plus has the potential to regulate innate immune response by acting on NOD-like and Toll-like signaling pathways to promote interferons production, activate and balance T-cells, and regulate the inflammatory response by inhibiting PI3K/AKT, NF-kappa B and MAPK signaling pathways. All these biological processes and pathways have been well documented in CoV infections studies. Therefore, our findings suggest that VCG Plus may be helpful in regulating immune response to combat CoV infections and inhibit excessive inflammatory responses to prevent the onset of cytokine storm. However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements.