Central nervous system interleukin-8 production following neck of femur fracture
Central nervous system interleukin-8 production following neck of femur fracture
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DOI：
10.1111/j.1445-2197.2005.03530.x
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发表时间：
2005-09-01
影响因子：
1.7
通讯作者：
Hill, AG
中科院分区：
文献类型：
--
作者：
Chuang, D;Power, SE;Hill, AG
目的：目的：建立创伤后脑脊液（CSF）中促炎细胞因子的表达谱。背景：创伤后综合征包括体重和氮的减少、发热、厌食和疲劳。已经提出细胞因子在此综合征的病理生理参与，但这些的作用部位尚不清楚。以前的工作在头部损伤模型，动物工作的支持下，已经表明，一个重要的网站的行动是中枢神经系统（CNS）。方法：妇女谁持续股骨颈骨折入组（创伤组）。在脊髓麻醉时收集CSF。接受选择性下肢手术的女性被招募作为对照。结果：创伤组脑脊液中IL-8升高，血清中IL-6升高，脑脊液中IL-6无变化;与IL-12升高相关的IL-1 β也在11名创伤患者中的3名血清中检测到，但在9名对照组中没有检测到。没有其他细胞因子一致determined.Conclusions：这项研究提出了一种可能性，即IL-8，在中枢神经系统中发挥作用，在伤后综合征中发挥作用。CNS IL-8在创伤中产生的机制尚不清楚，但CNS产生IL-8的已知能力和CNS中存在其作用的受体支持了生理作用。
Aim: To establish a proinflammatory cytokine profile of the cerebrospinal fluid (CSF) following trauma.Background: Trauma is associated with a postinjury syndrome consisting of loss of weight and nitrogen, pyrexia, anorexia and fatigue. It has been proposed that cytokines are pathophysiologically involved in this syndrome but the site of action of these is unclear. Previous work in head injury models, supported by animal work, has suggested that one important site of action is the central nervous system (CNS).Methods: Women who had sustained neck of femur fractures were enrolled (trauma group). CSF was collected at the time of spinal anaesthetic. Women undergoing elective lower limb surgery were recruited as controls. CSF and serum were assayed for Interleukin (IL) 1, 2, 4, 6, 8, 10, 12, interferon gamma, and tumour necrosis factor by cytometric bead array.Results: In the trauma group, IL-8 was elevated in the CSF but not in the serum, while IL-6 was elevated in the serum but not in the CSF. IL-1 beta, associated with elevated IL-12, was also detected in the serum of three of 11 trauma patients but none of the nine controls. No other cytokines were consistently detected.Conclusions: This study raises the possibility that IL-8, acting in the CNS, plays a role in the postinjury syndrome. It is unclear as to the mechanism by which CNS IL-8 is produced in trauma but a physiological role is supported by the known ability of the CNS to produce IL-8 and the presence of receptors for its action in the CNS.