BIOLOGICAL-ACTIVITY OF SOME OXYGENATED STEROLS
BIOLOGICAL-ACTIVITY OF SOME OXYGENATED STEROLS
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DOI：
10.1126/science.663671
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
HEINIGER, HJ
中科院分区：
文献类型：
--
作者：
KANDUTSCH, AA;CHEN, HW;HEINIGER, HJ
一组氧合甾醇被确定为甾醇生物合成的有效和特异性抑制剂。这些化合物在培养细胞中抑制甾醇合成的能力和胆固醇在相同条件下的无效表明，对甾醇生物合成的反馈调节可能是由氧化的甾醇而不是胆固醇带来的。调节固醇的性质在不同的细胞中可能因其对胆固醇作为结构成分或作为其他类固醇产物的前体的特定需求而有所不同。利用氧化甾醇阻断体外培养细胞中的甾醇合成，为甾醇在细胞膜结构和功能中的作用提供了新的信息。例如，一些培养细胞的DNA合成和细胞分裂需要从头合成甾醇。对培养细胞以及对大鼠和小鼠的体内研究表明，氧化甾醇可能在治疗几种重要的人类疾病方面具有价值。
A group of oxygenated sterols was identified as potent and specific inhibitors of sterol biosynthesis. The ability of these compounds to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated sterol rather than by cholesterol. The nature of the regulatory sterol may vary in different cells with their specific requirements for cholesterol as a structural component or as a precursor of other steroid products. The use of oxygenated sterols to block sterol synthesis in cultured cells provides new information regarding the role of sterol in cell membrane structure and function. For example, de novo sterol synthesis is required for DNA synthesis and cell division by some cultured cells. Studies with cultured cells, and with rats and mice in vivo, suggest that oxygenated sterols could be of value in the treatment of several important human diseases.