Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study
Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study
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DOI：
10.1093/oxfordjournals.aje.a009895
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发表时间：
1999-05-01
影响因子：
5
通讯作者：
Greger, JL
中科院分区：
文献类型：
--
作者：
Lyle, BJ;Mares-Perlman, JA;Greger, JL
在比弗坝眼科研究（比弗坝，威斯康星州）中，研究了一组43-84岁的成年人中抗氧化营养素与核性白内障发病率的关系。使用基线（1988-1990年）和随访（1993-1995年）时拍摄的透镜照片，以五点顺序量表评估核混浊度。在1 354名合格者中，246人至少有一只眼睛出现核性白内障（4级或5级混浊）。抗氧化剂的摄入量进行了评估，使用食物频率问卷调查，在基线对应的时间点，在基线前一年和基线前10年（遥远的过去）的摄入量。叶黄素-玉米黄质是唯一的类胡萝卜素，在五个检查，这是与核性白内障，在遥远的过去，叶黄素摄入量最高的五分之一的人有一半的可能性有一个事件白内障的摄入量最低的五分之一的人（95%置信区间0.3-0.8）。在总体组中，核性白内障与维生素C或维生素E的摄入量没有显著相关性。然而，维生素C和E与有其他白内障风险因素的人的混浊呈负相关。虽然这项短期随访研究的结果与叶黄素和维生素E和C对核性白内障发展的可能保护作用一致，但本研究中的证据为这些关联提供了微弱的支持。
The relation of antioxidant nutrients to the incidence of nuclear cataracts was investigated in a cohort of adults aged 43-84 years in the Beaver Dam Eye Study (Beaver Dam, Wisconsin). Nuclear opacity was assessed on a five-point ordinal scale using lens photographs taken at baseline (1988-1990) and at follow-up (1993-1995). Of the 1,354 persons eligible, 246 developed a nuclear cataract (level 4 or 5 opacity) in at least one eye. Antioxidant intakes were assessed using a food frequency questionnaire administered at baseline for time points corresponding to intake during the year preceding baseline and 10 years before baseline (the distant past). Lutein-zeaxanthin was the only carotenoid, out of five examined, that was associated with nuclear cataracts, Persons in the highest quintile of lutein intake in the distant past were half as likely to have an incident cataract as persons in the lowest quintile of intake (95% confidence interval 0.3-0.8). In the overall group, nuclear cataracts were not significantly related to intake of vitamin C or vitamin E. However, vitamins C and E were inversely associated with opacities in persons who had some other risk factors for cataracts. While results of this short term follow-up study are consistent with a possible protective influence of lutein and vitamins E and C on the development of nuclear cataracts, the evidence in the present study provides weak support for these associations.