Interactions between brain angiotensin and prostaglandins in rats.
Interactions between brain angiotensin and prostaglandins in rats.
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大鼠脑血管紧张素和前列腺素之间的相互作用。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
D. Ganten
中科院分区：
文献类型：
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作者：
B. Schölkens;R. Steinbach;D. Ganten
本实验研究了洋地黄素（PG）对脑局部血管紧张素Ⅱ（ANG Ⅱ）生成的影响及脑ANG Ⅱ的血压效应。在吲哚美辛预处理的Sprague-Dawley大鼠侧脑室注射肾素。注射肾素后15分钟，消炎痛治疗组和未治疗组的脑脊液（CSF）中ANG I和ANG II浓度以剂量依赖性方式显着且同等增加。在60分钟，ANG I在两组中均降低，在吲哚美辛预处理的动物中更显著。侧脑室（ICV）注射PGI_2可诱导CSF中显著的局部ANG Ⅱ形成，而不影响血浆肾素浓度。ICV肾素注射后，血压呈剂量依赖性、持续时间长（超过2小时）的升高。吲哚美辛预处理增加了ICV肾素的血压效应。ICV ANG II注射增加BP。用PGI_2或PGE_1预处理ICV可抑制中枢ANG Ⅱ升压反应。这些研究表明，PG衰减，而其生物合成的抑制增强了内源性脑血管紧张素II在大鼠的BP效应。提示PG可能作为ANG Ⅱ中枢作用的抑制性调节剂，参与了肾素血管紧张素系统（RAS）的反馈机制。
Experiments were performed to investigate the influence of prostaglandins (PG) on local angiotensin II (ANG II) generation in the brain and on the blood pressure (BP) effects of brain ANG II. In indomethacin pretreated Sprague-Dawley rats renin was injected into the lateral brain ventricle. At 15 min after renin injections cerebrospinal fluid (CSF) concentrations of ANG I and ANG II were markedly and equally increased in a dose-dependent manner in the indomethacin treated and in the untreated groups. At 60 min ANG I decreased in both groups, more marked in indomethacin pretreated animals. Intracerebroventricular (ICV) injections of PGI2 induced a marked local ANG II formation in CSF without effecting plasma renin concentration. ICV renin injections were followed by dose-dependent, long lasting (greater than 2 h) BP increases. Pretreatment with indomethacin increased the BP effects of ICV renin. ICV ANG II injections increased BP. ICV pretreatment with either PGI2 or PGE1 inhibited the central ANG II pressor responses. These studies indicate that PG attenuate whereas inhibition of their biosynthesis enhances the BP effects of endogenous brain ANG II in rats. It is suggested that PG may act as inhibitory modulators of the central actions of ANG II and they may participate in feedback mechanisms of the renin angiotensin system (RAS).