SEX STEROIDS AND SEX-HORMONE BINDING GLOBULIN IN MALES WITH CHRONIC-ALCOHOLISM
SEX STEROIDS AND SEX-HORMONE BINDING GLOBULIN IN MALES WITH CHRONIC-ALCOHOLISM
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DOI：
10.1111/j.1365-2362.1978.tb00841.x
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发表时间：
1978-01-01
影响因子：
5.5
通讯作者：
CHRISTENSEN, T
中科院分区：
文献类型：
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作者：
LINDHOLM, J;FABRICIUSBJERRE, N;CHRISTENSEN, T
对30例慢性酒精中毒患者进行了研究。所有患者均进行了肝脏和睾丸的活检。测定血清总和非蛋白结合(游离)睾酮、雌二醇、双氢睾酮和性激素结合球蛋白(SHBG)的浓度。大多数患者的睾酮和双氢睾酮浓度正常，而大约50%的患者雌二醇和游离雌二醇水平高于正常水平。在有肝硬化者和无肝硬化者之间，测量的激素没有显著差异。生精功能严重减退的男性与生发上皮完整的男性相比，SGBG显著升高，但在患有和不伴有肝硬变的男性之间没有差异。没有证据表明性腺功能减退的临床症状与所测量的任何激素之间存在联系。慢性酒精中毒患者可能会出现荷尔蒙和性功能紊乱，与肝病无关。
Thirty men with chronic alcoholism were studied. Biopsies of the liver and testis were performed in all. Serum concentrations of total and non-protein bound (free) testosterone and estradiol, dihydrotestosterone and sex-hormone binding globulin (SHBG) were determined. Testosterone and dihydrotestosterone concentrations were normal in most patients, whereas estradiol and free estradiol were above normal in approximately 50% of the patients. None of the hormones measured differed significantly between patients with and without cirrhosis. SGBG was significantly higher in men with severely reduced spermatogenesis compared to those with intact germinal epithelium, but there was no difference between men with and without cirrhosis. No relation could be demonstrated between clinical signs of hypogonadism and any of the hormones measured. Hormonal and sexual disturbances may occur in chronic alcoholism independent of the presence of liver disease.