Simultaneous formation and mineralization of star-P(EO-stat-PO) hydrogels.
Simultaneous formation and mineralization of star-P(EO-stat-PO) hydrogels.
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DOI：
10.1016/j.msec.2017.02.088
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Martha Schamel;J. Groll;U. Gbureck
中科院分区：
文献类型：
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作者：
Martha Schamel;J. Groll;U. Gbureck
天然骨是高度有序的胶原纤维和约60-70%纳米晶羟基磷灰石（HA）晶体的有机-无机复合物，在各种机械载荷情况下具有高抗断裂性。本研究旨在合成高矿化水凝胶以模拟松质骨的力学性能。用异氰酸酯基团作为反应性末端官能化的六臂星星分子（NCO-sP（EO-stat-PO））用于构建水凝胶基质，然后在结合的α-磷酸三钙颗粒水解之后，用羟基磷灰石纳米晶体矿化水凝胶基质。与简单地向水凝胶中添加非反应性填料颗粒相比，这种双重固化方法的优点被证明是强度提高了30倍。固化1-28 d后，含30 wt% NCO-sP（EO-stat-PO）的复合材料的弹性（5.3-1.4%）、压缩强度（11-23 MPa）和弹性模量（211-811 MPa）等力学性能与松质骨相似。
Natural bone is an organic-inorganic composite of highly ordered collagen fibrils and ~ 60–70% nanocrystalline hydroxyapatite (HA) crystals resulting in a high fracture resistance for various mechanical loading situations. This study aimed to synthesize highly mineralized hydrogels to mimic the mechanical properties of cancellous bone. A six armed star molecule functionalized with isocyanate groups as reactive termini (NCO–sP(EO-stat-PO)) was used to build up a hydrogel matrix, which was then subsequently mineralized with hydroxyapatite nanocrystals following the hydrolysis of incorporated α-tricalcium phosphate particles. The advantage of this dual setting approach in comparison to simply adding unreactive filler particles to the hydrogel was demonstrated to be a strength improvement by the factor of 30. After 1–28 d setting, the mechanical properties of a composite with 30 wt% NCO–sP(EO-stat-PO) such as elasticity (5.3–1.4%), compression strength (11–23 MPa) and E-modulus (211–811 MPa) were found to be similar to the properties of cancellous bone.