Feasibility study for the non-invasive blood pressure estimation based on ppg morphology: normotensive subject study.
Feasibility study for the non-invasive blood pressure estimation based on ppg morphology: normotensive subject study.
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DOI：
10.1186/s12938-016-0302-y
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发表时间：
2017-01-10
影响因子：
3.9
通讯作者：
Min SD
中科院分区：
文献类型：
--
作者：
Shin H;Min SD
血压是一个重要的生物信号，随着社会老龄化和心血管疾病人口的增长，血压的重要性也日益增加。然而，由于血压的测量依赖于基于袖带的技术，大多数高血压患者在日常生活中遭受了血压监测的不便。目前有许多无袖带测量血压的试验，特别是基于光电容积描记（PPG）的研究以各种方式进行。本研究旨在假设血管壁运动与PPG的压力-流量关系之间的关系，并通过实验方法验证其适当性。通过近似模型对PPG波形进行简化，然后利用PPG的导数将其分析为血流的速度和加速度。最后，我们开发的压力指数（PI）作为一个估计因素的血压相结合的统计学显着段的光电容积脉搏波。25名受试者参加了实验。模拟结果显示，收缩压、脉压和平均动脉压的PI与血压的相关系数分别为R = 0.818、R = 0.827和R = 0.615，均具有统计学意义（P < 0.05）。目前的研究只能估计血压的相对变化，而不能找到绝对压力值。此外，建议的指数有舒张压跟踪的局限性。然而，结果表明，所提出的PI与血压在统计学上显著相关，这表明所提出的PI作为无袖带血压监测的有希望的附加参数。
Blood pressure is a critical bio-signal and its importance has been increased with the aged society and the growth of cardiovascular disease population. However, most of hypertensive patients have been suffered the inconvenience in monitoring blood pressure in daily life because the measurement of the blood pressure depends on the cuff-based technique. Nowadays there are many trials to measure blood pressure without cuff, especially, photoplethysmography (PPG) based research is carried out in various ways. Our research is designed to hypothesis the relationship between vessel wall movement and pressure-flow relationship of PPG and to validate its appropriateness by experimental methods. PPG waveform is simplified by approximate model, and then it is analyzed as the velocity and the acceleration of blood flow using the derivatives of PPG. Finally, we develop pressure index (PI) as an estimation factor of blood pressure by combining of statistically significant segments of photoplethysmographic waveform. Twenty-five subjects were participated in the experiment. As a result of simulation, correlation coefficients between developed PI and blood pressure were represented with R = 0.818, R = 0.827 and R = 0.615 in systolic blood pressure, pulse pressure and mean arterial pressure, respectively, and both of result showed the meaningful statistically significance (P < 0.05). Current study can estimate only the relative variation of blood pressure but could not find the absolute pressure value. Moreover, proposed index has the limitation of diastolic pressure tracing. However, the result shows that the proposed PI is statistically significantly correlated with blood pressures, and it suggests that the proposed PI as a promising additional parameter for the cuff less blood pressure monitoring.