Genome-wide patterns of genetic variation among elite maize inbred lines
Genome-wide patterns of genetic variation among elite maize inbred lines
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DOI：
10.1038/ng.684
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发表时间：
2010-11-01
期刊：
影响因子：
30.8
通讯作者：
Wang, Jun
中科院分区：
文献类型：
--
作者：
Lai, Jinsheng;Li, Ruiqiang;Wang, Jun
我们已经对一组六个优良玉米自交系进行了重新测序，其中包括中国最具生产力的商业杂交种的亲本。这项工作在玉米基因组中发现了超过1，000，000个SNP，30，000个indel多态性和101个低序列多样性染色体间隔。我们还确定了数百个完整的基因，显示这些重新测序的线之间的存在/不存在的变化。我们讨论了互补的存在/不存在的变化和其他有害的突变，有助于杂种优势的潜在作用。高密度SNP和indel多态性标记有望为这一重要作物的遗传研究和分子育种提供宝贵的资源。
We have resequenced a group of six elite maize inbred lines, including the parents of the most productive commercial hybrid in China. This effort uncovered more than 1,000,000 SNPs, 30,000 indel polymorphisms and 101 low-sequence-diversity chromosomal intervals in the maize genome. We also identified several hundred complete genes that show presence/absence variation among these resequenced lines. We discuss the potential roles of complementation of presence/absence variations and other deleterious mutations in contributing to heterosis. High-density SNP and indel polymorphism markers reported here are expected to be a valuable resource for future genetic studies and the molecular breeding of this important crop.