Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia
Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia
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DOI：
10.1007/s12185-017-2368-0
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发表时间：
2018-01-01
影响因子：
2.1
通讯作者：
Kaneko, Kiriko
中科院分区：
文献类型：
--
作者：
Furuyama, Kazumichi;Kaneko, Kiriko
铁粒幼细胞性贫血是以患者骨髓中存在环形铁粒幼细胞为特征的贫血性疾病。这些疾病通常分为两种类型，先天性或获得性铁粒幼细胞性贫血。最近，一些基因被报道为负责先天性铁粒幼细胞性贫血，然而，基因产物和环形铁粒幼细胞的功能之间的关系在很大程度上是不清楚的。在这篇综述文章中，我们将集中在红系细胞以及先天性铁粒幼细胞性贫血患者的铁代谢。
Sideroblastic anemias are anemic disorders characterized by the presence of ring sideroblasts in a patient's bone marrow. These disorders are typically divided into two types, congenital or acquired sideroblastic anemia. Recently, several genes were reported as responsible for congenital sideroblastic anemia; however, the relationship between the function of the gene products and ring sideroblasts is largely unclear. In this review article, we will focus on the iron metabolism in erythroid cells as well as in patients with congenital sideroblastic anemia.