Nitric oxide inhalation and nitric oxide synthase inhibitor supplement for endotoxin-induced hypotension
Nitric oxide inhalation and nitric oxide synthase inhibitor supplement for endotoxin-induced hypotension
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DOI：
10.1046/j.1442-200x.2001.01419.x
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发表时间：
2001-08-01
影响因子：
1.4
通讯作者：
Haas, KM
中科院分区：
文献类型：
--
作者：
Suzuki, S;Togari, H;Haas, KM
背景资料：本研究旨在探讨吸入一氧化氮（NO）和一氧化氮合酶（NOS）抑制剂联合治疗内毒素诱导的屈光性低血压伴肺动脉高压的有效性。方法：10头新生仔猪经大肠杆菌脂多糖（1 mg/kg）诱导内毒素血症。然后在60分钟后开始实验，此时全身动脉压下降。吸入20 p. p.m. NO在60和120分钟的内毒素血症创建一个对照组。另一组在第一次吸入NO后60 min给予N-硝基-L-精氨酸（L-NNA; 5 mg）（L-NNA组）。结果：对照组5头仔猪中有3头死于失血性休克，L-NNA组5头仔猪中有3头死于失血性休克，L-NNA组5头仔猪的体循环动脉压恢复到内毒素给药前水平。L-NNA组产生了进一步增加肺动脉压对NO吸入是effected.Conclusion：一氧化氮吸入单独进行了一个潜在的风险，进一步降低全身动脉压在一只小猪与低血压引起的内毒素，而联合治疗导致的血压恢复到前内毒素水平。联合治疗对肺动脉高压同时有效。
Background: This study was performed to determine whether a combined therapy of nitric oxide (NO) inhalation and nitric oxide synthase (NOS) inhibitor is effective in experimental animals with endotoxin-induced refractive hypotension accompanied by pulmonary hypertension.Methods: Escherichia coli lipopolysaccharide (I mg/kg) was administered to 10 newborn piglets to induce endotoxemia. The experiment then began 60 min later, when the systemic arterial pressure dropped. The inhalation of 20 p.p.m. NO at 60 and 120 min of endotoxemia created a control group. Another group was also administered N w-nitro-L-arginine (L-NNA; 5 mg) after the first NO inhalation at 60 min of endotoxemia (the L-NNA group). Pulmonary arterial pressure, systemic arterial pressure and cardiac output were measured and compared among the groups.Results: Three of the 5 piglets in the control group died of hypotensive shock, while in the L-NNA group the systemic arterial pressure recovered to pre-endotoxin administration levels. The L-NNA group produced a further increase in pulmonary arterial pressure against which NO inhalation was effective.Conclusion: Nitric oxide inhalation alone carries a potential risk of further lowering systemic arterial pressure in a piglet with hypotension induced by endotoxin, whereas the combined therapy resulted in the recovery of the blood pressure to pre-endotoxin levels. The combined therapy was simultaneously effective against pulmonary hypertension.