Gender does not matter: Add-on repetitive transcranial magnetic stimulation treatment for female methamphetamine dependents
Gender does not matter: Add-on repetitive transcranial magnetic stimulation treatment for female methamphetamine dependents
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性别并不重要：针对女性甲基苯丙胺依赖者的附加重复经颅磁刺激治疗
DOI：
10.1016/j.pnpbp.2018.12.018
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发表时间：
2019-06-08
影响因子：
5.6
通讯作者：
Yuan, Ti-Fei
中科院分区：
文献类型：
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作者：
Liu, Ting;Li, Yongqiang;Yuan, Ti-Fei
背景：针对前额叶皮层的重复经颅磁刺激（rTMS）可以减少不同类型药物成瘾者的渴求。然而，由于入组的女性受试者比例较小，大多数研究未能阐明治疗效果的潜在性别差异。方法：将90例女性甲基苯丙胺依赖者随机分为对照组（常规戒毒）和附加10 Hz组（常规戒毒加20次rTMS治疗）。药物相关线索的渴望分数进行了检查，作为此treatment.Results的主要结果：结果表明，添加rTMS治疗是有效的女性甲基苯丙胺依赖，治疗后的效果持续至少30天。药物滥用史预测慢性治疗的疗效，TMS治疗的效果是更明显的年轻，高渴望subjects.Conclusions：添加高频率rTMS治疗是耐受性和有效的女性甲基苯丙胺依赖。
Background: Repetitive transcranial magnetic stimulation (rTMS) targeting prefrontal cortex reduces craving in different types of drug addiction. However, most studies failed to elucidate the potential gender discrepancies for the treatment effects, due to the small percentage of female subjects enrolled. The present study prospectively recruited female methamphetamine dependents for TMS treatment.Methods: Ninety female methamphetamine dependents were randomly assigned into the control group (routine addiction rehabilitation) or add-on 10 Hz group (routine addiction rehabilitation plus 20 times rTMS treatments). The craving scores to drug associated cues were examined as the primary outcome for this treatment.Results: The results showed that add-on rTMS treatment was as well effective in female methamphetamine dependents, and the effect lasted for at least 30 days after treatment. Drug abuse history predicts the efficacy of chronic treatment, and the effects of TMS treatment was more pronounced in young, high-craving subjects.Conclusions: Add-on high frequency rTMS treatment is as well tolerable and effective in female methamphetamine dependents.