Pancreatic cancer-associated diabetes mellitus: Prevalence and temporal association with diagnosis of cancer
Pancreatic cancer-associated diabetes mellitus: Prevalence and temporal association with diagnosis of cancer
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DOI：
10.1053/j.gastro.2007.10.040
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发表时间：
2008-01-01
期刊：
影响因子：
29.4
通讯作者：
Petersen, Gloria M.
中科院分区：
文献类型：
--
作者：
Chari, Suresh T.;Leibson, Cynthia L.;Petersen, Gloria M.
背景与目的：糖尿病与胰腺癌之间的时间相关性尚不清楚。我们比较了胰腺癌和对照组糖尿病患病率的时间模式。方法：我们回顾了明尼苏达州罗切斯特120英里以内的胰腺癌病例的医疗记录，这些病例在2004年1月15日至2004年7月9日期间在梅奥诊所就诊，并有大约2个居住在当地的配对对照/病例。我们提取了所有门诊患者60个月的空腹血糖(FBG)水平，并将其分组为12个月的间隔；736例患者和1875名对照组在病历中有1个或1个以上的门诊空腹血糖(FBG)水平。糖尿病被定义为任何空腹血糖水平等于或大于126 mg/dL或接受糖尿病治疗，并被定义为糖尿病标准在指数前24个月或更短时间内首次达到时的新发病，且至少先前空腹血糖水平低于126 mg/dL。结果：与对照组相比，胰腺癌患者在指数前60个月内的任何时候都符合糖尿病标准的比例更高(40.2%对19.2%，P
Background & Aim: The temporal association between diabetes mellitus and pancreatic cancer is poorly understood. We compared temporal patterns in diabetes prevalence in pancreatic cancer and controls. Methods: We reviewed the medical records of pancreatic cancer cases residing within 120 miles or less of Rochester, Minnesota, seen at the Mayo Clinic between January 15, 198 1, and July 9, 2004, and approximately 2 matched controls/case residing locally. We abstracted all outpatient fasting blood glucose (FBG) levels for up to 60 months before index (ie, date of cancer diagnosis for cases) and grouped them into 12-month intervals; 736 cases and 1875 controls had 1 or more outpatient FBG levels in the medical record. Diabetes was defined as any FBG level of 126 mg/dL or greater or treatment for diabetes, and was defined as new onset when criteria for diabetes were first met 24 or fewer months before index, with at least I prior FBG level less than 126 mg/dL. Results: A higher proportion of pancreatic cancer cases compared with controls met the criteria for diabetes at any time in the 60 months before index (40.2% vs 19. 2%, P