Glucose Tolerance Stages in Cystic Fibrosis Are Identified by a Unique Pattern of Defects of Beta-Cell Function
Glucose Tolerance Stages in Cystic Fibrosis Are Identified by a Unique Pattern of Defects of Beta-Cell Function
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DOI：
10.1210/clinem/dgaa932
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发表时间：
2021-04-01
影响因子：
5.8
通讯作者：
Maffeis, Claudio
中科院分区：
文献类型：
--
作者：
Piona, Claudia;Volpi, Sonia;Maffeis, Claudio
目的：我们旨在评估囊性纤维化（CF）患者葡萄糖调节的3个直接决定因素- β细胞功能，胰岛素清除率和胰岛素敏感性缺陷的严重程度，根据他们的糖耐量状态进行分类，包括早期中期口服糖耐量试验（OGTT）葡萄糖值（bbb140和bbb140）升高
Objective: We aimed to assess the order of severity of the defects of 3 direct determinants of glucose regulation-beta-cell function, insulin clearance, and insulin sensitivity-in patients with cystic fibrosis (CF), categorized according their glucose tolerance status, including early elevation of mid-level oral glucose tolerance test (OGTT) glucose values (>140 and