A DISCRETE-EVENT SIMULATION APPROACH TO IDENTIFY RULES THAT GOVERN ARBOR REMODELING FOR BRANCHING CUTANEOUS AFFERENTS IN HAIRY SKIN.
A DISCRETE-EVENT SIMULATION APPROACH TO IDENTIFY RULES THAT GOVERN ARBOR REMODELING FOR BRANCHING CUTANEOUS AFFERENTS IN HAIRY SKIN.
复制标题
一种离散事件模拟方法，用于识别多毛皮肤中分支皮肤传入的乔木重塑规则。
DOI：
10.1109/wsc.2017.8247992
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Gerling,GregoryJ
中科院分区：
文献类型：
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作者：
Kang,Hyojung;Orlowsky,RachelL;Gerling,GregoryJ
在哺乳动物中，触觉由嵌入皮肤的感觉受体编码。对于小鼠中的一类受体，其默克尔细胞、无髓鞘神经突和半突的结构在4至10周龄的毛发周期阶段遵循特定的更新和重塑趋势。由于目前不可能在单个动物的毛发周期中观察到这种趋势，因此这项工作采用离散事件模拟来识别和评估默克尔细胞和半节点动力学的政策。与观察到的数据很好地匹配，结果显示基线模型复制了毛发周期阶段之间的动态重塑行为-基于特定的添加和去除策略以及与默克尔细胞、末端分支神经突和半突的组成部分相关的估计概率。分析还表明，某些政策的影响力大于其他政策。这种计算的使用是理解神经元发育的一种新方法。
In mammals, touch is encoded by sensory receptors embedded in the skin. For one class of receptors in the mouse, the architecture of its Merkel cells, unmyelinated neurites, and heminodes follow particular renewal and remodeling trends over hair cycle stages from ages 4 to 10 weeks. As it is currently impossible to observe such trends across a single animal's hair cycle, this work employs discrete event simulation to identify and evaluate policies of Merkel cell and heminode dynamics. Well matching the observed data, the results show that the baseline model replicates dynamic remodeling behaviors between stages of the hair cycle - based on particular addition and removal polices and estimated probabilities tied to constituent parts of Merkel cells, terminal branch neurites and heminodes. The analysis shows further that certain policies hold greater influence than others. This use of computation is a novel approach to understanding neuronal development.