Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis.
Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis.
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IgG4 相关泪腺炎和唾液腺炎中产生白细胞介素 5 的 ST2 记忆 Th2 细胞。
DOI：
10.1080/14397595.2018.1526357
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Takahashi H.
中科院分区：
文献类型：
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作者：
Yamamoto M;Takano KI;Kamekura R;Aochi S;Suzuki C;Ichimiya S;Nakase H;Himi T;Takahashi H.
目的：免疫球蛋白(Ig)G4相关疾病(IgG4-RD)常合并变态反应性疾病。本研究旨在探讨IgG4相关性泪腺炎和涎腺炎(IgG4-DS)患者外周血中辅助性T细胞2型炎症(Th2-炎症)的发生机制。方法：采用流式细胞术分离分析IgG4-DS患者和正常人外周血单个核细胞中生长刺激表达基因2(ST2)+记忆性Th2细胞的比例。结果：IgG4-DS患者外周血中ST2+记忆Th2细胞比例明显高于正常对照组。受累唾液腺和淋巴结中可见大量的ST2+记忆Th2细胞，这些细胞产生IL-5。结论：在IgG4-DS受累组织中，产生IL-5的ST2+记忆Th2细胞增加。这一亚群细胞被认为是诱导IgG4-DS的炎性Th2环境特征的重要参与者。
Objectives:Immunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS).Methods:We separated and analyzed the proportion of growth stimulation expressed gene 2 (ST2)+memory Th2 cells among the peripheral blood mononuclear cells by flow cytometry in cases with IgG4-DS and healthy individuals. Finally, we identified the role of ST2+memory Th2 cells in the involved tissues.Results:The proportion of circulating ST2+memory Th2 cells was much higher in the patients with IgG4-DS than in the healthy controls. Abundant infiltration of ST2+memory Th2 cells was detected in the involved salivary glands and lymph nodes, and these cells produced interleukin-5.Conclusion:We demonstrated that there is an increase of interleukin-5 producing ST2+memory Th2 cells in the involved tissues in IgG4-DS. This subset of cells is considered to be an important player in inducing the inflammatory Th2 environment characteristic of IgG4-DS.