Muscle sympathetic outflow during horizontal linear acceleration in humans
Muscle sympathetic outflow during horizontal linear acceleration in humans
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DOI：
10.1152/ajpregu.2001.281.2.r625
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发表时间：
2001-08-01
影响因子：
2.8
通讯作者：
Mori, S
中科院分区：
文献类型：
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作者：
Cui, J;Iwase, S;Mori, S
为了阐明直线加速对人体肌肉交感神经活动(MSNA)的影响，在直线加速器中对16名健康男性进行了测试。在直线加速过程中测量MSNA、心电图、血压和胸阻抗。正弦线加速度，峰值在+/-0.10、+/-0.15和+/-0.20G，在前后(+/-G(X)，n=10)或横向(+/-G(Y)，n=6)施加。在向前、向后、向左或向右直线加速过程中，MSNA的总活动度和突发率显著降低。在直线加速过程中，四个方向的MSNA总活性分别从基线(100%)下降到50.56.9、52.5+/-4.4、71.2+/-9.6和67.6+/-8.2%，峰值分别位于+/-0.20G。这些结果表明，在被动运动引起的姿势反射中，对耳石器官水平方向的动态刺激可能直接抑制MSNA，以便迅速将血液重新分配到肌肉，这支持了前庭系统参与人类交感神经调节的概念。
To elucidate the effects of linear acceleration on muscle sympathetic nerve activity (MSNA) in humans, 16 healthy men were tested in a linear accelerator. Measurements of MSNA, electrocardiogram, blood pressure, and thoracic impedance were undertaken during linear acceleration. Sinusoidal linear acceleration with peak values at +/-0.10, +/-0.15, and +/-0.20 G was applied in anteroposterior (+/-G(X), n = 10) or lateral (+/-G(y), n = 6) directions. The total activity and burst rate of MSNA decreased significantly during forward, backward, left, or right linear accelerations. The total activity of MSNA decreased to 50.56.9, 52.5 +/-4.4, 71.2 +/-9.6, and 67.6 +/-8.2% from the baselines (100%) during linear accelerations with peak values at +/-0.20 G in the four directions, respectively. These results suggest that dynamic stimulation of otolith organs in horizontal directions in humans might inhibit MSNA directly in order to quickly redistribute blood to muscles during postural reflexes induced by passive movement, which supports the concept that the vestibular system contributes to sympathetic regulation in humans.