Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye
Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye
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DOI：
10.1016/s0014-4800(03)00009-1
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发表时间：
2003-04-01
影响因子：
3.6
通讯作者：
Goodglick, L
中科院分区：
文献类型：
--
作者：
Wadehra, M;Sulur, GG;Goodglick, L
上皮膜蛋白2（EMP2）是四跨膜超家族（TM4SF）的成员，被认为可介导多种蛋白质（如α6β1整合素和I类主要组织相容性复合体）向脂筏微区的运输。最近在某些模型系统中，EMP2也被认为是一种潜在的肿瘤抑制基因。正常情况下，EMP2在身体的特定部位表达，包括在眼睛、肺、心脏、甲状腺和子宫中高水平表达。在此我们详细研究了EMP2在小鼠和人眼组织中的亚解剖分布。我们观察到EMP2定位于角膜、睫状体和视网膜色素上皮 - 脉络膜的上皮层、巩膜的基质层以及视网膜和视神经的神经纤维层。这种分布与其他TM4SF蛋白不同，可能与顶端膜循环的作用有关。（C）2003爱思唯尔科学（美国）。版权所有。
Epithelial membrane protein-2 (EMP2) is a member of the four transmembrane superfamily (TM4SF) and is thought to mediate trafficking of diverse proteins such as alpha6beta1 integrin and MHC class I to lipid raft microdomains. EMP2 has also recently been recognized as a putative tumor suppressor gene in certain model systems. Normally, EMP2 is expressed at discrete locations in the body including high levels in the eye, lung, heart, thyroid, and uterus. Here we examine in detail the subanatomic distribution of EMP2 in murine and human ocular tissue. We observe that EMP2 is localized to epithelial layers of the cornea, ciliary body, and retinal pigmented epithelium-choroid, the stromal layers of the sclera, and the nerve fiber layer of the retina and optic nerve. This distribution is distinct from other TM4SF proteins and may relate to a role in apical membrane recycling. (C) 2003 Elsevier Science (USA). All rights reserved.