Fluid pressure distribution due to outer hair cell excitation in a 3‐D dual chamber model of cochlea
Fluid pressure distribution due to outer hair cell excitation in a 3‐D dual chamber model of cochlea
复制标题
耳蜗 3D 双腔模型中外毛细胞激发引起的流体压力分布
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
A. Nuttall
中科院分区：
文献类型：
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作者：
A. Parthasarathi;K. Grosh;T. Ren;A. Nuttall
在这项研究中，基底膜（BM）的速度和总的流体压力分布所产生的激励只外毛细胞（OHC）在耳蜗中的特定位置进行建模。使用标准理想化（例如矩形横截面和满足拉普拉斯方程的线性无粘流体）对耳蜗进行建模。使用两个流体腔室，在耳蜗分区（CP）的上方和下方各一个。由BM、OHC、静纤毛和覆膜（TM）组成的简化的微力学模型代表CP。使用混合有限元法求解的配方。OHC的局部激发导致流体压力扰动，其向心尖和镫骨传播（排放）。稳态和瞬态响应，以及在顶点，圆窗，椭圆窗的边界条件的影响将被呈现。将发射结果与沙鼠的电诱发耳声发射进行比较，以确定模型的能力。
In this study, basilar membrane (BM) velocity and the total fluid pressure distributions arising from exciting only the outer hair cells (OHCs) at a particular location in the cochlea are modeled. The cochlea is modeled using standard idealizations such as rectangular cross‐section and linear inviscid fluid satisfying Laplace’s equation. Two fluid chambers, one each above and below the cochlear partition (CP), are used. A simplified micromechanical model consisting of the BM, OHC, stereocilia, and tectorial membrane (TM) represents the CP. The formulation is solved using a hybrid finite element method. A localized excitation of the OHCs causes fluid pressure disturbances, which propagate toward the apex and stapes (emissions). Both steady state and transient responses, and also the influence of boundary conditions at the apex, round window, and the oval window will be presented. Emission results will be compared to electrically evoked otoacoustic emissions for gerbils to determine the ability of the model...