Microsporidia: how can they invade other cells?
Microsporidia: how can they invade other cells?
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DOI：
10.1016/j.pt.2004.04.009
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发表时间：
2004-06-01
影响因子：
9.6
通讯作者：
Franzen, C
中科院分区：
文献类型：
--
作者：
Franzen, C
微孢子虫是专性细胞内真核寄生虫，具有独特的感染宿主细胞的机制。微孢子虫孢子含有一根从孢子中伸出的长卷曲极管，可以穿透新宿主细胞的细胞膜。然后孢子的内容物被迫通过管进入宿主细胞的细胞质。最近的研究表明，微孢子虫还可以通过吞噬作用进入宿主细胞。然而，吞噬作用后，小孢子极管被用来逃离成熟的吞噬体并感染宿主细胞的细胞质。
Microsporidia are obligate intracellular eukaryotic parasites that have a distinctive mechanism for infecting host cells. Microsporidian spores contain a long coiled polar tube that extrudes from the spores and can penetrate the membranes of new host cells. The contents of the spores are then forced through the tubes into the host cell cytoplasm. Recent studies have shown that microsporidia also gain access to host cells by phagocytosis. However, after phagocytosis, the microsporidian polar tube is used to escape from the maturing phagosomes and to infect the cytoplasm of host cells.