To drink or not to drink: Tests of anxiety and immobility in alcohol-preferring and alcohol-nonpreferring rat strains
To drink or not to drink: Tests of anxiety and immobility in alcohol-preferring and alcohol-nonpreferring rat strains
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DOI：
10.1016/0031-9384(94)00368-f
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发表时间：
1995-05
影响因子：
2.9
通讯作者：
I. V. Viglinskaya;D. Overstreet;O. Kashevskaya;B. A. Badishtov;A. Kampov-Polevoy;S. Seredenin;J. Halikas
中科院分区：
文献类型：
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作者：
I. V. Viglinskaya;D. Overstreet;O. Kashevskaya;B. A. Badishtov;A. Kampov-Polevoy;S. Seredenin;J. Halikas
先前的报告对自愿大量饮酒的老鼠的情绪状态提供了不同的结果。本研究的目的是比较几种酒精偏好大鼠（P、AA、FH）与几种酒精不偏好大鼠（NP、ANA、FRL）和莫兹利菌株在焦虑和不动测试中的表现。在约70日龄时，将大鼠置于高架+迷宫中进行5分钟的测试；4天后进行10分钟的强迫游泳试验，4天后进行改良的强迫游泳试验（胶囊），其中有4个假逃生通道。FRL大鼠在高架+迷宫的张开双臂中花费的时间比任何其他品系都多，但高架+迷宫得分与酒精摄入量之间没有一致的关系。在标准强迫游泳试验中，偏好酒精的P型大鼠最活跃，而不偏好酒精的莫兹利反应型大鼠最不活跃，但总体而言，不动与酒精摄入之间没有一致的关系。所有的大鼠在胶囊中都更活跃，没有明显的品系差异。然而，偏好酒精的P和FH大鼠比其他品系更倾向于逃跑，这导致了逃跑尝试与酒精摄入量之间的总体显著相关性。这些发现并没有为嗜酒老鼠通过饮酒来减少高度焦虑状态的假设提供任何支持。
Previous reports have provided mixed results about emotional states in rats that voluntarily drink substantial amounts of alcohol. The purpose of the present study was to compare several strains of alcohol-preferring rats (P, AA, FH) with several strains of alcohol-nonpreferring rats (NP, ANA, FRL), and the Maudsley strains on tests reflecting anxiety and immobility. At about 70 days of age the rats were placed in the elevated plus maze for a 5-min test; a forced swim test of 10 min was given 4 days later and this test was followed 4 days later by a modified forced swim test (the capsule), in which there were four false escape alleys. The FRL rats spent more time in the open arms of the elevated plus maze than any other strain, but there was no consistent relationship between elevated plus maze scores and alcohol intake. The alcohol-preferring P rats were the most active in the standard forced swim test and the alcohol-nonpreferring Maudsley Reactive rats were the least active, but there was no consistent relationship between immobility and alcohol intake overall. All rats were much more active in the capsule and there were no significant strain differences. However, the alcohol-preferring P and FH rats attempted to escape more than the other strains, resulting in an overall significant correlation between escape attempts and alcohol intake. These findings do not provide any support for the hypothesis that alcohol-preferring rats are drinking alcohol to reduce high anxiety states.