SURFACE REMODELING OF RETICULOCYTES PRODUCED IN RESPONSE TO ERYTHROID STRESS
SURFACE REMODELING OF RETICULOCYTES PRODUCED IN RESPONSE TO ERYTHROID STRESS
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DOI：
10.1038/newbio236157a0
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
SHOHET, SB
中科院分区：
文献类型：
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作者：
COME, SE;ROBINSON, SH;SHOHET, SB
加速红细胞生成与过大网织红细胞的产生有关，可能是骨髓中红细胞增殖期间跳过分裂的结果1。同位素研究已被解释为显示这些“应激网织红细胞”是短暂的，并被具有更正常寿命的逐渐变小的细胞所取代1 -6。然而，最近有人提出，应激性网织红细胞并没有完全被破坏，而是通过重塑或表面碎裂的过程而变小7;这些细胞的仅部分损失可以解释大多数同位素结果，尽管残留的细胞可能保持完整。
ACCELERATED erythropoiesis is associated with the production of reticulocytes of excessive size, perhaps as the result of skipped divisions during erythroid cell proliferation in the bone marrow1. Isotopic studies have been interpreted as showing that these “stress reticulocytes” are short-lived and are replaced by progressively smaller cells with more normal life spans1–6. It has recently been suggested, however, that stress reticulocytes are not destroyed in toto but are made smaller by a process of remodelling or surface fragmentation7; loss of only portions of these cells could explain most of the isotopic findings, although the residual cells might remain intact.