FINAL CASE REPORTING FROM THE UGANDAN PROSPECTIVE-STUDY OF THE RELATIONSHIP BETWEEN EBV AND BURKITTS-LYMPHOMA
FINAL CASE REPORTING FROM THE UGANDAN PROSPECTIVE-STUDY OF THE RELATIONSHIP BETWEEN EBV AND BURKITTS-LYMPHOMA
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DOI：
10.1002/ijc.2910290406
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发表时间：
1982-01-01
影响因子：
6.4
通讯作者：
WILLIAMS, EH
中科院分区：
文献类型：
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作者：
GESER, A;DETHE, G;WILLIAMS, EH
1972年至1979年在乌干达西尼罗河地区进行了一项前瞻性流行病学研究，以调查EB病毒（EBV）在伯基特淋巴瘤（BL）中的病因作用。到1976年，在研究地区最初流血的的42，000名儿童中发现了14例BL病例。对BL候选者和邻居对照的血清检测表明，后来发展为BL的儿童的EBV/VCA（病毒衣壳抗原）滴度比他们年龄和性别匹配的邻居高出几个稀释度。这种在BL发展之前很久就出现的强EBV活性被认为是EBV在BL中的因果作用的证据。为了增加出血前BL病例的独特材料，BL检测一直持续到1979年3月，当时乌干达的实地工作变得不可能。在本研究扩展期间，发现了另外2例预出血BL病例。这些额外病例的血清学和病毒学评价显示，BL候选者中的EBV/VCA滴度比对照组高约2倍，但EA [早期抗原]和EBNA [EB病毒核抗原]滴度不高。杂交分析表明，这两个淋巴瘤的肿瘤细胞中含有EBV/DNA。因此，额外的结果证实了前14例中的发现，并加强了流行病学证据的因果作用的EB病毒在地方性BL。
A prospective epidemiological study was carried out in the West Nile District of Uganda from 1972 to 1979 to investigate the etiological role of the Epstein-Barr virus (EBV) in Burkitt''s lymphoma (BL). By 1976, 14 BL cases had been detected among the 42,000 children originally bled in the study area. Testing of sera from BL candidates and neighborhood controls showed that children who developed BL later had EBV/VCA [viral capsid antigen] titres several dilutions higher than their age- and sex-matched neighbors. This appearance of a strong EBV activity long before BL development was taken as evidence of a causal role of EBV in BL. To add to the unique material of pre-bled BL cases, BL detection was continued up to March 1979 when field work became impossible in Uganda. Two additional pre-bled BL cases were found during this extension of the study. The serological and virological evaluation of these additional cases showed that the EBV/VCA titers, but not the EA [early antigen] and EBNA [Epstein-Barr Virus nuclear antigen] titers, were about 2 dilutions higher in the BL candidates than in the controls. Hybridization assays showed that both lymphomas contained EBV/DNA in the tumor cells. The additional results thus confirm the findings in the first 14 cases and strengthen the epidemiological evidence for a causal role of the EBV in endemic BL.