Association of bedtime with the risk of non-alcoholic fatty liver disease among middle-aged and elderly Chinese adults with pre-diabetes and diabetes
Association of bedtime with the risk of non-alcoholic fatty liver disease among middle-aged and elderly Chinese adults with pre-diabetes and diabetes
复制标题
中国中老年糖尿病前期和糖尿病患者就寝时间与非酒精性脂肪肝风险的关系
DOI：
10.1002/dmrr.3322
复制
发表时间：
2020-09-01
影响因子：
8
通讯作者：
Lu, Jieli
中科院分区：
文献类型：
--
作者：
Hu, Chunyan;Zhang, Yi;Lu, Jieli
背景新的证据表明，睡眠特征可能在代谢紊乱的发展中起重要作用。然而，对于糖尿病前期和糖尿病患者中就寝时间与非酒精性脂肪性肝病（NAFLD）风险之间的关系知之甚少。方法前瞻性队列研究10 375名年龄≥ 40岁的成年人，从3484名符合条件的糖尿病前期和糖尿病个体中筛选出1960名参与本研究。在基线和随访时使用肝脏超声诊断NAFLD。在基线时使用标准问卷获得就寝时间信息。结果我们在本研究人群中记录了433例NAFLD事件。在多变量调整的logistic回归模型中，晚睡与NAFLD风险增加相关（晚睡每小时风险增加29%）。与就寝时间= 22：00的个体相比，分别为1.56（1.04-2.34）和2.05（1.31-3.20）。在亚组分析中，在超重或缺乏身体活动的人，或患有代谢综合征或动脉粥样硬化性心血管疾病10年风险升高的人中观察到显著相关性。当估计就寝时间和其他睡眠特征的联合作用时，在晚睡/早起、晚睡/午睡（是）、晚睡/睡眠不好或晚睡/睡眠时间较短的组中观察到NAFLD事件的风险较高。结论：在糖尿病前期和糖尿病成人中，晚睡时间与NAFLD发生风险增加显著相关，强调了睡眠行为管理在预防NAFLD中的重要性。
Background Emerging evidence indicated that sleep characteristics may play important roles in the development of metabolic disorders. However, little is known as to the association between bedtime and the risk of non-alcoholic fatty liver disease (NAFLD) in individuals with pre-diabetes and diabetes. Methods In a prospective cohort of 10 375 adults aged >= 40 years, 1960 of 3484 eligible pre-diabetic and diabetic individuals were identified for the current study. NAFLD was diagnosed using liver ultrasonography at baseline and at follow-up. Information on bedtime was obtained at baseline using a standard questionnaire. Results We documented 433 incident cases of NAFLD among this study population. In multivariable-adjusted logistic regression model, later bedtime was associated with increased risk of NAFLD (29% increased risk per hour of later bedtime). Compared to individuals with bedtime = 22:00 were 1.56 (1.04-2.34) and 2.05 (1.31-3.20), respectively. In the subgroup analysis, significant associations were observed among those who were overweight or physically inactive, or those with metabolic syndrome or elevated 10-year risks for atherosclerotic cardiovascular disease. When estimating the joint effect of bedtime and other sleep characteristics, higher risk of incident NAFLD was observed in groups of late bed/early rise, late bed/napping (yes), late bed/bad sleeper, or late bed/shorter sleep durations. Conclusions Later bedtime was significantly associated with an increased risk of incident NAFLD in adults with pre-diabetes and diabetes, underscoring the importance of sleep behaviour management in the prevention of NAFLD.