IMPACT OF WEIGHT-LOSS ON PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1), FACTOR-VII, AND OTHER HEMOSTATIC FACTORS IN MODERATELY OVERWEIGHT ADULTS
IMPACT OF WEIGHT-LOSS ON PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1), FACTOR-VII, AND OTHER HEMOSTATIC FACTORS IN MODERATELY OVERWEIGHT ADULTS
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DOI：
10.1161/01.atv.13.2.162
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发表时间：
1993-02-01
期刊：
影响因子：
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通讯作者：
WU, KK
中科院分区：
文献类型：
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作者：
FOLSOM, AR;QAMHIEH, HT;WU, KK
基于以前的横断面研究结果，我们假设体重减轻可以改善与心血管疾病相关的几个止血因素。在一项随机对照试验中，中度超重的男性和女性被分配到四个减肥治疗组之一或对照组。在基线和6个月后，对90名男性和88名女性进行了纤溶酶原激活物抑制剂-1（派-1）抗原、组织型纤溶酶原激活物（t-PA）抗原、D-二聚体抗原、因子VII活性、纤维蛋白原和蛋白C抗原的测量。男性和女性的净治疗体重减轻分别为9.4 kg和7.4 kg。D-二聚体、纤维蛋白原或蛋白C在体重减轻时无净变化（p>0.05）。显著（p
Based on previous cross-sectional findings, we hypothesized that weight loss could improve several hemostatic factors associated with cardiovascular disease. In a randomized controlled trial, moderately overweight men and women were assigned to one of four weight loss treatment groups or to a control group. Measurements of plasminogen activator inhibitor-1 (PAI-1) antigen, tissue-type plasminogen activator (t-PA) antigen, D-dimer antigen, factor VII activity, fibrinogen, and protein C antigen were made at baseline and after 6 months in 90 men and 88 women. Net treatment weight loss was 9.4 kg in men and 7.4 kg in women. There was no net change (p>0.05) in D-dimer, fibrinogen, or protein C with weight loss. Significant (p