Skin and subcutaneous blood flows of very low birth weight infants during the first 3 postnatal days
Skin and subcutaneous blood flows of very low birth weight infants during the first 3 postnatal days
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DOI：
10.3109/14767050903188992
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发表时间：
2010-06-01
影响因子：
1.8
通讯作者：
Igarashi, Takashi
中科院分区：
文献类型：
--
作者：
Ishiguro, Akio;Sekine, Takashi;Igarashi, Takashi
目标。目的：探讨用新型激光多普勒血流仪测量皮肤和皮下血流量对极低出生体重儿(VLBW)出生后早期心血管状况的评估价值。对2007年5月至2008年4月在东京大学医院出生的8例极低出生体重儿和8例非极低出生体重儿进行连续72h额部和肢体皮肤血流量测定，平均每8h采集一次数据，进行t检验。极低出生体重儿的额部血流量从测量开始至32h开始增加(16.6±3.9ml/min比24.1+/-2.1ml/min；p=0.002比8h)，此后保持不变。下肢血流量在24 h后迅速增加(22.2+/-5.5ml/min vs.29.5+/-5.0ml/min；p=0.002，与8h相比)，此后继续增加。相反，非极低出生体重儿的血流量保持不变。结果表明，极低出生体重儿皮肤和皮下血流灌注在24小时左右自发增加，与非极低出生体重儿血流变化的差异表明，这些参数成功地反映了极低出生体重儿组织血流灌注的生理性变化。
Objective. To determine whether skin and subcutaneous blood flow measurements using a novel laser Doppler flow meter are useful for evaluating the cardiovascular status of very low birth weight (VLBW) infants during the early postnatal period.Methods. In eight VLBW infants and eight non-VLBW infants born at Tokyo University Hospital between May 2007 and April 2008, forehead and lower limb skin blood flows were measured continuously for 72 h. Data were averaged every 8 h, and the t-test was used for analysis.Results. In VLBW infants, forehead blood flow started to increase from the start of measurement to 32 h (16.6 +/- 3.9 ml/min vs. 24.1 +/- 2.1 ml/min; p = 0.002 compared with 8 h) and remained constant thereafter. Lower limb blood flow increased rapidly after 24 h (22.2 +/- 5.5 ml/min vs. 29.5 +/- 5.0 ml/min; p = 0.002 compared with 8 h) and continued increasing thereafter. In contrast, blood flows remained constant in non-VLBW infants.Conclusions. The results showed that skin and subcutaneous perfusion in VLBW infants increased spontaneously at around 24 h. Differences in blood flow changes between VLBW and non-VLBW infants demonstrate that these parameters successfully identified physiological changes in tissue perfusion in VLBW infants.