Ultrasound ionization of biomolecules
Ultrasound ionization of biomolecules
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DOI:
10.1002/rcm.4677
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发表时间:
2010-09-01
影响因子:
2
通讯作者:
Chen, Chung-Hsuan
中科院分区:
文献类型:
--
作者:
Wu, Chen-I;Wang, Yi-Sheng;Chen, Chung-Hsuan
To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules. Copyright (C) 2010 John Wiley & Sons, Ltd.