Point of Care Diagnostics in Resource-Limited Settings: A Review of the Present and Future of PoC in Its Most Needed Environment.
Point of Care Diagnostics in Resource-Limited Settings: A Review of the Present and Future of PoC in Its Most Needed Environment.
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DOI：
10.3390/bios10100133
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发表时间：
2020-09-24
期刊：
影响因子：
--
通讯作者：
Cleij TJ
中科院分区：
文献类型：
--
作者：
Heidt B;Siqueira WF;Eersels K;Diliën H;van Grinsven B;Fujiwara RT;Cleij TJ
即时诊断是政府行动、非政府组织和基础研究的重点。在高收入国家，希望简化诊断程序，最大限度地降低成本，并使医疗保健过程更高效、更快速，在某些情况下，这可能更多地是为了方便而不是必要。然而，在诸如低收入国家等资源有限的环境中，pocc诊断可能是唯一可行的途径，因为下一个实验室要几个小时才能到达。因此，特别重要的是集中研究这些国家的新型诊断方法，以减轻传染病造成的痛苦。在这篇综述中，总结了目前关于在资源有限的环境中使用PoC诊断的研究，以及阻碍其广泛应用的价值链上的潜在瓶颈。为此，我们将查看研究价值链不同部分的文献，例如基础研究和市场经济学，以及医疗保健提供者的实际使用。我们的目标是从大学研究的第一次开始到该领域的患者治疗，创建一个潜在的PoC障碍的综合图片。将讨论文献的结果，目的是将所有重要步骤和方面结合起来，以说明在低收入国家如何有效地使用PoC。此外，我们还讨论了进一步改善这种情况所需要做的事情，以便充分利用该技术，避免当一个有前途的设备未能采取下一步的增值途径而被放弃时“管道中的泄漏”。
Point of care (PoC) diagnostics are at the focus of government initiatives, NGOs and fundamental research alike. In high-income countries, the hope is to streamline the diagnostic procedure, minimize costs and make healthcare processes more efficient and faster, which, in some cases, can be more a matter of convenience than necessity. However, in resource-limited settings such as low-income countries, PoC-diagnostics might be the only viable route, when the next laboratory is hours away. Therefore, it is especially important to focus research into novel diagnostics for these countries in order to alleviate suffering due to infectious disease. In this review, the current research describing the use of PoC diagnostics in resource-limited settings and the potential bottlenecks along the value chain that prevent their widespread application is summarized. To this end, we will look at literature that investigates different parts of the value chain, such as fundamental research and market economics, as well as actual use at healthcare providers. We aim to create an integrated picture of potential PoC barriers, from the first start of research at universities to patient treatment in the field. Results from the literature will be discussed with the aim to bring all important steps and aspects together in order to illustrate how effectively PoC is being used in low-income countries. In addition, we discuss what is needed to improve the situation further, in order to use this technology to its fullest advantage and avoid “leaks in the pipeline”, when a promising device fails to take the next step of the valorization pathway and is abandoned.
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影响因子：
8.1
作者：
Engel N;Wachter K;Pai M;Gallarda J;Boehme C;Celentano I;Weintraub R
通讯作者：
Weintraub R
影响因子：
9.3
作者：
Ciaranello AL;Park JE;Ramirez-Avila L;Freedberg KA;Walensky RP;Leroy V
通讯作者：
Leroy V
影响因子：
3.1
作者：
Gift, TL;Pate, MS;Kassler, WJ
通讯作者：
Kassler, WJ
加纳出生时获得护理的地理通道：安全母性的障碍。
影响因子：
4.5
作者：
Gething PW;Johnson FA;Frempong-Ainguah F;Nyarko P;Baschieri A;Aboagye P;Falkingham J;Matthews Z;Atkinson PM
通讯作者：
Atkinson PM
影响因子：
3.7
作者：
Girdwood, Sarah J.;Nichols, Brooke E.;Rosen, Sydney
通讯作者：
Rosen, Sydney