Preclinical testing of a new clot-retrieving wire device using polyvinyl alcohol hydrogel vascular models
Preclinical testing of a new clot-retrieving wire device using polyvinyl alcohol hydrogel vascular models
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DOI：
10.1007/s00234-006-0181-1
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发表时间：
2007-03-01
期刊：
影响因子：
2.8
通讯作者：
Goto, Katsuya
中科院分区：
文献类型：
--
作者：
Asakura, Fumio;Yilmaz, Hasan;Goto, Katsuya
前言脑栓塞是脑梗死的主要原因。近年来，机械性取栓术已被认为是一种有效的方法。我们进行了一个新的机械clot-retrieving wire.Methods这clot-retrieving wire包括三个镍钛合金环在微导丝的尖端的临床前评价。这三个环可折叠到0.018英寸导丝兼容微导管中。每个环长8 mm，宽3.5 mm。为了模拟，构建了人颈动脉（8个模型）和椎基底动脉（3个模型）循环的聚乙烯醇（PVA）血管解剖模型。使用脉动流循环系统。使用猪血浆产生栓塞凝块。将微导管和微导丝推进到凝块之外。然后将导丝更换为回收导丝。然后将微导管略微拉回以打开环。然后通过撤回系统捕获凝块。一旦捕获，将凝块回收到导引导管头端。我们调查了以下几点：易于设备部署，凝块捕获能力，凝块清除对血流和清除凝块的介绍system.Results共进行了104个程序中的11个PVA模型和评价。下降率为19%。51.0%（53/104）的手术在30分钟内成功实现部分和完全再通。结论这种新的取栓钢丝可用于脑卒中的机械取栓。
Introduction Cerebral embolism is the principal cause of cerebral infarction. Recently, mechanical embolectomy has been proposed as an effective method. We performed a preclinical evaluation of a new mechanical clot-retrieving wire.Methods This clot-retrieving wire consisted of three nitinol loops at the tip of a microguidewire. These three loops could be collapsed into a 0.018-inch wire compatible microcatheter. Each loop was 8 mm long and 3.5 mm wide. For simulation, polyvinyl alcohol (PVA) vascular anatomical models of the human carotid (eight models) and vertebrobasilar (three models) circulation were constructed. A pulsatile flow circulation system was used. Embolic clots were produced using pig blood plasma. The microcatheter and the microguidewire were advanced beyond the clot. The wire was then exchanged for the retrieving wire. The microcatheter was then pulled slightly back to open the loops. The clot was then caught by withdrawal of the system. Once caught, the clot was retrieved to the guiding catheter tip. We investigated the following points: ease of device deployment, clot capture ability, clot removal against blood flow and removal of the clot out of the introducer system.Results A total of 104 procedures were performed in 11 PVA models and evaluated. The drop rate was 19%. We succeeded in partial and total recanalization in 51.0% of the procedures (53/104) within 30 minutes.Conclusion This new clot-retrieving wire could be useful for mechanical clot extraction in stroke.