Roles of attention, memory, and motor preparation in modulating human brain activity in a spatial working memory task.
Roles of attention, memory, and motor preparation in modulating human brain activity in a spatial working memory task.
复制标题
注意力、记忆和运动准备在空间工作记忆任务中调节人脑活动中的作用。
DOI：
10.1093/cercor/8.1.80
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Salenius,S
中科院分区：
文献类型：
--
作者：
Okada,YC;Salenius,S
用脑磁图（MEG）研究了人类大脑在空间工作记忆任务中的神经元活动，类似于非人类灵长类动物的工作记忆任务。被试被要求记住目标位置3秒，并通过举指比较被测目标与被测目标的位置做出相同不同的判断，或者对被测目标执行记忆引导的扫视。在这种类型的任务中，单单元研究表明，在保留间隔期间，灵长类动物的大量皮质区域（包括顶叶和前额叶区域）存在独立于运动类型的注意和记忆相关活动。与这些结果一致的是，在保留期间，有强烈的刺激驱动的短暂和持续的反应和振荡活动的调节。虽然我们没有确定信号的来源位置，但粗略估计的脑电信号显示，大脑皮层的大部分区域都有活动，最明显的是罗兰区、顶叶区和枕叶区，但额叶区也有活动。这些皮层区域的一些活动反映了可能与注意力和记忆有关的过程，而其他活动则与显性运动的准备有关。
Neuronal activity of the human brain was studied with magnetoencephalography (MEG) in a spatial working memory task similar to those commonly used with nonhuman primates. The subject was required to remember target positions for 3 s and make a same-different judgement with a finger lift comparing the position of the probed target with the probe or to execute a memory-guided saccade to the probed target. In this type of task single-unit studies have shown attention- and memory-related activities independent of movement type during the retention interval in a large number of cortical areas of the primates, including the parietal and prefrontal areas. Consistent with these results, there were strong stimulus-driven transient and sustained responses and modulations of oscillatory activity during the retention period. Although we did not determine the source locations, coarse estimates of the currents responsible for the MEG signals showed activity over a wide area of the cortex, most prominently over the Rolandic, parietal and occipital areas, but also over the frontal area. Some of the activities in these cortical areas reflect processes that may be identified with attention and memory, while others were related to preparation of the overt movements.