miR-199b-5p modulates BMSC osteogenesis via suppressing GSK-3β/β-catenin signaling pathway
miR-199b-5p modulates BMSC osteogenesis via suppressing GSK-3β/β-catenin signaling pathway
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DOI：
10.1016/j.bbrc.2016.06.130
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发表时间：
2016-09-02
影响因子：
3.1
通讯作者：
Zhu, Yong
中科院分区：
文献类型：
--
作者：
Zhao, Ruibo;Li, Yusheng;Zhu, Yong
miR-199 b-5 p在人骨髓基质细胞（BMSCs）成骨过程中显著上调。抑制miR-199 b-5 p显著降低BMSCs的成骨分化，而过表达miR-199 b-5 p则促进BMSCs的成骨分化，这可能与成骨基因表达、ALP活性和ARS染色的矿化结节的变化有关。miR-199 b-5 p在BMSC成骨中发挥作用最可能是通过GSK-3 β/β-连环蛋白信号通路。总之，本研究首次揭示了miR-199 b-5 p在成骨细胞分化中起积极作用。(C)2016年6月，作者。爱思唯尔公司出版
miR-199b-5p is up-regulated significantly during the osteogenesis process in human bone marrow stromal cells (BMSCs). Inhibiting miR-199b-5p notably reduces while over-expressing miR-199b-5p promotes the BMSCs osteoblast differentiation, suggested by the alternations of osteogenic genes expression, ALP activity and the ARS-stained mineral nodules. miR-199b-5p exerts its role in BMSC osteogenesis most probably through the GSK-3 beta/beta-catenin signaling pathway. In conclusion, the present study revealed for the first time that miR-199b-5p plays a positive role in osteoblast differentiation. (C) 2016 The Authors. Published by Elsevier Inc.