Automatic interface‐controlled apheresis collection of stem/progenitor cells: results from an autologous donor validation trial of a novel stem cell apheresis device
Automatic interface‐controlled apheresis collection of stem/progenitor cells: results from an autologous donor validation trial of a novel stem cell apheresis device
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干细胞/祖细胞的自动接口控制单采采集：新型干细胞单采设备的自体供体验证试验的结果
DOI：
10.1111/j.1537-2995.2010.02992.x
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发表时间：
2011
期刊：
影响因子：
2.9
通讯作者：
H. Bonig
中科院分区：
文献类型：
--
作者：
P. Reinhardt;Susanne Brauninger;H. Bialleck;Kristin Thorausch;Richard Smith;H. Schrezenmeier;E. Seifried;M. Wiesneth;H. Bonig
背景技术背景：通过单采术从粒细胞集落刺激因子联合或不联合化疗动员的患者中收集的冻存造血祖细胞已成为支持治疗适合大剂量化疗的疾病的首选自体移植类型。构建了一种新型单采系统Spectra Optia v.5.0（CaridianBCT），以满足手动单采系统（如COBE Spectra MNC（CaridianBCT））的某些缺点，包括需要连续光学或手动监测和重新调整血沉棕黄层位置以及对不一致血流的敏感性。通过使用提供真实的实时自动界面（血沉棕黄层）和采集线控制的光学传感器，Spectra Optia有望自动指导单采程序，从而可能节省操作员时间并降低采集效率的变化性（CE 2）。
BACKGROUND: Cryopreserved hematopoietic progenitor cells collected by apheresis from granulocyte–colony‐stimulating factor with or without chemotherapy–mobilized patients have become the preferred type of autograft to support treatment of diseases amenable to high‐dose chemotherapy. A novel apheresis system, the Spectra Optia v.5.0 (CaridianBCT), was constructed to meet certain shortcomings of manual apheresis systems such as the COBE Spectra MNC (CaridianBCT), including the need for continuous optical or manual monitoring and readjustment of buffy coat position and sensitivity to inconsistent blood flow. By use of optical sensors, which provide real‐time automatic interface (buffy coat) and collection line control, the Spectra Optia promises to automatically guide apheresis procedures, potentially freeing up operator time and reducing variability in collection efficiency (CE2).
影响因子：
20.3
作者：
Bonig, Halvard;Wundes, Annette;Papayannopoulou, Thalia
通讯作者：
Papayannopoulou, Thalia