The Role of Extracellular Vesicles in Liver Pathogenesis.
The Role of Extracellular Vesicles in Liver Pathogenesis.
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DOI：
10.1016/j.ajpath.2022.06.007
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发表时间：
2022-06
期刊：
影响因子：
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通讯作者：
Gang Liu;X. Yin
中科院分区：
文献类型：
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作者：
Gang Liu;X. Yin
细胞外小泡(EV)是由细胞以外体、微泡和凋亡小体的形式产生的。它们可以被邻近的细胞吸收，其内容物可能会对吞噬它们的细胞产生功能影响。作为细胞间通讯的媒介，EVS在生理和病理环境中都可以发挥重要作用。此外，早期检测不同体液中的EVS可能为某些疾病提供敏感的诊断工具，如癌症。此外，针对特定的电动汽车也可能成为一种有前途的治疗方法。本文综述了EVS在肝脏研究领域的最新发现，重点介绍了EVS的不同内容及其对肝功能的影响，以及对肝脏炎症、纤维化和肿瘤的发展的影响。这篇综述的目的是简明扼要地描述能够调节电动汽车功能的各种分子，以便读者可以将这些知识应用到他们自己的研究中。
Extracellular vesicles (EVs) are generated by cells in the form of exosomes, microvesicles, and apoptotic bodies. They can be taken up by neighboring cells, and their contents can have functional impact on the cells that engulf them. As the mediators of intercellular communication, EVs can play important roles in both physiological and pathologic contexts. In addition, early detection of EVs in different body fluids may offer a sensitive diagnostic tool for certain diseases, such as cancer. Furthermore, targeting specific EVs may also become a promising therapeutic approach. This review summarizes the latest findings of EVs in the field of liver research, with a focus on the different contents of the EVs and their impact on liver function and on the development of inflammation, fibrosis, and tumor in the liver. The goal of this review is to provide a succinct account of the various molecules that can mediate the function of EVs so the readers may apply this knowledge to their own research.