Long Noncoding Competing Endogenous RNA Networks in Pancreatic Cancer.
Long Noncoding Competing Endogenous RNA Networks in Pancreatic Cancer.
复制标题
胰腺癌中的长非编码竞争性内源 RNA 网络
DOI：
10.3389/fonc.2021.765216
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Qin R
中科院分区：
文献类型：
--
作者：
Xiong G;Pan S;Jin J;Wang X;He R;Peng F;Li X;Wang M;Zheng J;Zhu F;Qin R
胰腺癌（PC）是一种高度恶性疾病，具有发病隐匿、进展快、治疗效果差的特点。与PC的启动和进展相关的分子机制在很大程度上是不够的，阻碍了开发新的诊断生物标志物和开发有效的治疗策略。近年来的研究表明，非编码RNA（ncRNA），包括长链ncRNA（lncRNA）和微小RNA（miRNAs），广泛参与了PC的发病机制。具体来说，lncRNA可以作为竞争性内源性RNA（ceRNA）发挥作用，竞争性地隔离miRNA，从而调节其下游靶基因的表达水平。这种复杂的lncRNA/miRNA/mRNA网络，即ceRNA网络，通过调节细胞生长和存活、上皮-间充质转化和转移、癌症干细胞维持、代谢、自噬、化学抗性和血管生成在PC的生物学过程中发挥关键作用。在这篇综述中，新出现的知识在lncRNA相关的ceRNA网络参与PC的启动和进展进行了总结，竞争性串扰作为诊断，预后和治疗靶点的潜力将进行全面讨论。
Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the exploitation of novel diagnostic biomarkers and development of efficient therapeutic strategies. Emerging evidence recently reveals that noncoding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and microRNAs (miRNAs), extensively participate in PC pathogenesis. Specifically, lncRNAs can function as competing endogenous RNAs (ceRNAs), competitively sequestering miRNAs, therefore modulating the expression levels of their downstream target genes. Such complex lncRNA/miRNA/mRNA networks, namely, ceRNA networks, play crucial roles in the biological processes of PC by regulating cell growth and survival, epithelial–mesenchymal transition and metastasis, cancer stem cell maintenance, metabolism, autophagy, chemoresistance, and angiogenesis. In this review, the emerging knowledge on the lncRNA-associated ceRNA networks involved in PC initiation and progression will be summarized, and the potentials of the competitive crosstalk as diagnostic, prognostic, and therapeutic targets will be comprehensively discussed.