Childhood cancer And paternal employment in agriculture: the role of pesticides
Childhood cancer And paternal employment in agriculture: the role of pesticides
复制标题
DOI：
10.1038/bjc.1998.134
复制
发表时间：
1998-03-01
影响因子：
8.8
通讯作者：
Pannett, B
中科院分区：
文献类型：
--
作者：
Fear, NT;Roman, E;Pannett, B
以前的研究表明，在工作中可能接触农药的男性的后代患肾癌（肾母细胞瘤）、脑瘤、尤因骨肉瘤和急性白血病的风险可能会增加。本文在一个大型的国家数据库中研究了父亲潜在的农药职业暴露与子女癌症死亡之间的关系。记录167703儿童死亡发生在1959-63年，1970-78年和1979-90年在英格兰和威尔士进行了分析。在那些有可能职业性接触杀虫剂的男性的后代中，有5270人死亡，其中449人死于癌症。使用比例死亡率（PMR）评估相关性，并对年龄，死亡年份和父亲的社会阶层进行调整。在以前与父亲可能职业接触农药有关的儿童癌症中，唯一统计学上显著过量的是肾癌（PMR = 1.59，95%CI = 1.18-2.15，基于42例死亡）。虽然这些结果提供了一些支持的建议，父亲职业暴露于农药可能与随后的发展肾癌的后代，其他解释不能排除。根据这里和其他地方提出的调查结果，有必要对这种关系的性质进行进一步、更详细的研究。
Previous studies have suggested that the offspring of men potentially exposed to pesticides at work may be at increased risk of kidney cancer (Wilms' tumour), brain tumours, Ewing's bone sarcoma anti acute leukaemia. This paper examines the association between potential occupational exposure of fathers to pesticides and offspring's, death from cancer in a large national database. Records for 167703 childhood deaths occurring during 1959-63, 1970-78 and 1979-90 in England and Wales have been analysed. Among the offspring of men with potential occupational exposure to pesticides there were 5270 deaths, of which 449 were due to cancer. Associations were assessed using proportional mortality ratios (PMRs), with adjustment for age, year of death and paternal social class. Of the childhood cancers previously linked with potential paternal occupational exposure to pesticides, the only statistically significant excess was for kidney cancer (PMR = 1.59, 95% CI = 1.18-2.15, based on 42 deaths). Although these results offer some support for the suggestion that paternal occupational exposure to pesticides may be related to the subsequent development of kidney cancer in offspring, other explanations cannot be excluded. In the light of the findings presented here and elsewhere, further, more detailed, research into the nature of this relationship is warranted.