ETIOLOGIC PARALLEL BETWEEN ANAL CANCER AND CERVICAL-CANCER
ETIOLOGIC PARALLEL BETWEEN ANAL CANCER AND CERVICAL-CANCER
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DOI：
10.1016/0140-6736(91)91233-k
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发表时间：
1991-09-14
期刊：
影响因子：
168.9
通讯作者：
SPROGEL, P
中科院分区：
文献类型：
--
作者：
MELBYE, M;SPROGEL, P
据推测，感染因子和/或特定的性行为与肛门癌的病因有关，类似于宫颈癌的病因。 1968- 1987年间，对丹麦癌症登记处登记的29648名癌症妇女进行的病例对照研究验证了以下假设：肛门癌患者比结肠癌、胃癌或外阴癌患者更有可能既往诊断为宫颈上皮内瘤变（CIN）或浸润性宫颈癌。 经年龄和诊断年份校正后，肛门癌与结肠癌的CIN比值比为5.2（95%置信区间[CI] 3.3-8.3），肛门癌与胃癌的比值比为3.6（2.1-6.0），肛门癌与外阴癌的比值比为1.6（0.9-2.9）。 从诊断CIN到诊断登记癌症的中位时间为肛门151个月，外阴112个月，结肠114个月，胃癌126个月。 还研究了与既往浸润性宫颈癌的相关性;第二次分析中没有宫颈癌患者被纳入CIN分析。 优势比相似。 此外，肛门癌患者患宫颈癌的可能性明显高于外阴癌患者（比值比1.8 [1.0-3.9]）。 肛门癌和CIN/浸润性宫颈癌之间的强相关性表明这些癌症具有共同的风险因素。 这种关联至少与宫颈癌和外阴癌之间的关联一样强。
It has been postulated that an infectious agent and/or specific sexual behaviour is involved in the aetiology of anal cancer, in analogy with the aetiology established for cancer of the cervix. A case-control study of 29 648 women with cancers registered in the Danish Cancer Registry during 1968-87 tested the hypothesis that anal cancer patients were more likely than patients with colon, stomach, or vulva cancer to have had a previous diagnosis of cervical intraepithelial neoplasia (CIN) or invasive cervical cancer. The odds ratio of CIN, adjusted for age and year of diagnosis, for anal vs colon cancer was 5.2 (95% confidence interval [CI] 3.3-8.3), that for anal vs stomach cancer 3.6 (2.1-6.0), and that for anal vs vulva cancer 1.6 (0.9-2.9). The median time from diagnosis of CIN to diagnosis of the registered cancer was 151 months for anal, 112 months for vulva, 114 months for colon, and 126 months for stomach cancer. The association with previous invasive cervical cancer was also investigated; no patient with cervical cancer in this second analysis had been included in the CIN analysis. The odds ratios were similar. In addition, anal cancer patients were significantly more likely to have had cervical cancer than were patients with vulva cancer (odds ratio 1.8 [1.0-3.9]). The strong association between anal cancer and CIN/invasive cervical cancer suggests that these cancers share common risk factors. The association is at least as strong as that between cervical and vulva cancer.