Cochlear Outer-Hair-Cell Power Generation and Viscous Fluid Loss.
Cochlear Outer-Hair-Cell Power Generation and Viscous Fluid Loss.
复制标题
耳蜗外毛细胞发电和粘性液体损失。
DOI：
10.1038/srep19475
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发表时间：
2016
影响因子：
4.6
通讯作者：
Puria,Sunil
中科院分区：
文献类型：
--
作者：
Wang,Yanli;Steele,CharlesR;Puria,Sunil
自从发现耳声发射和外毛细胞（OHC）运动以来，耳蜗是否产生机械动力的基本问题仍然存在争议。在本工作中，直接计算了由于流体粘度和OHCs产生的功率损失。使用小鼠耳蜗的三维盒子模型，采用前馈/反馈近似表示Corti细胞结构的器官。该模型适用于含一个自由参数的基底膜内运动。计算结果表明，在声压级（SPL）为10 dB时，三排ohc的总输出功率比声输入功率大3个数量级以上。虽然先前的研究表明，功率增益或负阻尼随强度而减小，但我们明确地基于我们的模型表明，OHC功率输出随着声压级的增加而增加并趋于饱和。在80db SPL下，总OHC输出功率约为2pw，每OHC最大输出功率约为10fw。
Since the discovery of otoacoustic emissions and outer hair cell (OHC) motility, the fundamental question of whether the cochlea produces mechanical power remains controversial. In the present work, direct calculations are performed on power loss due to fluid viscosity and power generated by the OHCs. A three-dimensional box model of the mouse cochlea is used with a feed-forward/feed-backward approximation representing the organ of Corti cytoarchitecture. The model is fit toin vivobasilar membrane motion with one free parameter for the OHCs. The calculations predict that the total power output from the three rows of OHCs can be over three orders of magnitude greater than the acoustic input power at 10 dB sound pressure level (SPL). While previous work shows that the power gain, or the negative damping, diminishes with intensity, we show explicitly based on our model that OHC power output increases and saturates with SPL. The total OHC power output is about 2 pW at 80 dB SPL, with a maximum of about 10 fW per OHC.