Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
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DOI：
10.1038/ng.3654
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发表时间：
2016-10
期刊：
影响因子：
30.8
通讯作者：
Munroe, Patricia B.
中科院分区：
文献类型：
--
作者：
Surendran, Praveen;Drenos, Fotios;Young, Robin;Warren, Helen;Cook, James P.;Manning, Alisa K.;Grarup, Niels;Sim, Xueling;Barnes, Daniel R.;Witkowska, Kate;Staley, James R.;Tragante, Vinicius;Tukiainen, Taru;Yaghootkar, Hanieh;Masca, Nicholas;Freitag, Daniel F.;Ferreira, Teresa;Giannakopoulou, Olga;Tinker, Andrew;Harakalova, Magdalena;Mihailov, Evelin;Liu, Chunyu;Kraja, Aldi T.;Nielsen, Sune Fallgaard;Rasheed, Asif;Samue, Maria;Zhao, Wei;Bonnycastle, Lori L.;Jackson, Anne U.;Narisu, Narisu;Swift, Amy J.;Southam, Lorraine;Marten, Jonathan;Huyghe, Jeroen R.;Stancakova, Alena;Fava, Cristiano;Ohlsson, Therese;Matchan, Angela;Stirrups, Kathleen E.;Bork-Jensen, Jette;Gjesing, Anette P.;Kontto, Jukka;Perola, Markus;Shaw-Hawkins, Susan;Havulinna, Aki S.;Zhang, He;Donnelly, Louise A.;Groves, Christopher J.;Rayner, N. William;Neville, Matt J.;Robertson, Neil R.;Yiorkas, Andrianos M.;Herzig, Karl-Heinz;Kajantie, Eero;Zhang, Weihua;Willems, Sara M.;Lannfelt, Lars;Malerba, Giovanni;Soranzo, Nicole;Trabetti, Elisabetta;Verweij, Niek;Evangelou, Evangelos;Moayyeri, Alireza;Vergnaud, Anne-Claire;Nelson, Christopher P.;Poveda, Alaitz;Varga, Tibor V.;Caslake, Muriel;de Craen, Anton J. M.;Trompet, Stella;Luan, Jian'an;Scott, Robert A.;Harris, Sarah E.;Liewald, David C. M.;Marioni, Riccardo;Menni, Cristina;Farmaki, Aliki-Eleni;Hallmans, Goran;Renstrom, Frida;Huffman, Jennifer E.;Hassinen, Maija;Burgess, Stephen;Vasan, Ramachandran S.;Felix, Janine F.;Uria-Nickelsen, Maria;Malarstign, Anders;Reilly, Dermot F.;Hoek, Maarten;Vogt, Thomas F.;Lin, Honghuang;Lieb, Wolfgang;Traylor, Matthew;Markus, Hugh S.;Highland, Heather M.;Justice, Anne E.;Marouli, Eirini;Lindstrom, Jaana;Uusitupa, Matti;Komulainen, Pirjo;Lakka, Timo A.;Rauramaa, Rainer;Polasek, Ozren;Rudan, Igor;Rolandsson, Olov;Franks, Paul W.;Dedoussis, George;Spector, Timothy D.;Jousilahti, Pekka;Mannisto, Satu;Deary, Ian J.;Starr, John M.;Langenberg, Claudia;Wareham, Nick J.;Brown, Morris J.;Dominiczak, Anna F.;Connell, John M.;Jukema, J. Wouter;Sattar, Naveed;Ford, Ian;Packard, Chris J.;Esko, Tonu;Magi, Reedik;Metspalu, Andres;de Boer, Rudolf A.;van der Meer, Peter;van der Harst, Pim;Gambaro, Giovanni;Ingelsson, Erik;Lind, Lars;de Bakker, Paul I. W.;Numans, Mattijs E.;Brandslund, Ivan;Christensen, Cramer;Petersen, Eva R. B.;Korpi-Hyovalti, Eeva;Oksa, Heikki;Chambers, John C.;Kooner, Jaspal S.;Blakemore, Alexandra I. F.;Franks, Steve;Jarvelin, Marjo-Riitta;Husemoen, Lise L.;Linneberg, Allan;Skaaby, Tea;Thuesen, Betina;Karpe, Fredrik;Tuomilehto, Jaakko;Doney, Alex S. F.;Morris, Andrew D.;Palmer, Colin N. A.;Holmen, Oddgeir Lingaas;Hveem, Kristian;Willer, Cristen J.;Tuomi, Tiinamaija;Groop, Leif;Karajamaki, AnneMari;Palotie, Aarno;Ripatti, Samuli;Salomaa, Veikko;Alam, Dewan S.;Majmnder, Abdulla Al Shafi;Di Angelantonio, Emanuele;Chowdhury, Rajiv;McCarthy, Mark I.;Poulter, Neil;Stanton, Alice V.;Sever, Peter;Amouyel, Philippe;Arveiler, Dominique;Blankenberg, Stefan;Ferrieres, Jean;Kee, Frank;Kuulasmaa, Kari;Muller-Nurasyid, Martina;Veronesi, Giovanni;Virtamo, Jarmo;Deloukas, Panos;Elliott, Paul;Zeggini, Eleftheria;Kathiresan, Sekar;Melander, Olle;Kuusisto, Johanna;Laakso, Markku;Padmanabhan, Sandosh;Porteous, David J.;Hayward, Caroline;Scotland, Generation;Collins, Francis S.;Mohlke, Karen L.;Hansen, Torben;Pedersen, Oluf;Boehnke, Michael;Stringham, Heather M.;Frossard, Philippe;Newton-Cheh, Christopher;Tobin, Martin D.;Nordestgaard, Borge Gronne;Caulfield, Mark J.;Mahajan, Anubha;Morris, Andrew P.;Tomaszewski, Maciej;Samani, Nilesh J.;Saleheen, Danish;Asselbergs, Folkert W.;Lindgren, Cecilia M.;Danesh, John;Wain, Louise V.;Butterworth, Adam S.;Howson, Joanna M. M.;Munroe, Patricia B.
高血压是心血管疾病和过早死亡的主要危险因素。然而，对特定致病基因和途径的了解有限。为了更好地了解血压的遗传学，我们对约 192,000 名个体的 242,296 个罕见、低频和常见遗传变异进行了基因分型，并使用约 155,063 个样本进行独立复制。我们在普通人群中发现了 31 个新的血压或高血压相关基因区域，包括 RBM47、COL21A1 和 RRAS 中的三种罕见错义变异，其影响比常见变异更大（>1.5mmHg/等位基因）。在 A2ML1 中发现了多个罕见、无义和错义变体关联，并在 ENPEP 中发现了低频无义变体。我们的数据扩展了血压特征和高血压的等位基因变异谱，为高血压的病理生理学提供了新的见解，并为临床干预指明了新的目标。
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to ~192,000 individuals, and used ~155,063 samples for independent replication. We identified 31 novel blood pressure or hypertension associated genetic regions in the general population, including three rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5mmHg/allele) than common variants. Multiple rare, nonsense and missense variant associations were found in A2ML1 and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
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影响因子：
30.8
作者：
Arking, Dan E.;Pulit, Sara L.;Crotti, Lia;Van der Harst, Pim;Munroe, Patricia B.;Koopmann, Tamara T.;Sotoodehnia, Nona;Rossin, Elizabeth J.;Morley, Michael;Wang, Xinchen;Johnson, Andrew D.;Lundby, Alicia;Gudbjartsson, Daniel F.;Noseworthy, Peter A.;Eijgelsheim, Mark;Bradford, Yuki;Tarasov, Kirill V.;Dorr, Marcus;Miiller-Nurasyid, Martina;Lahtinen, Annukka M.;Nolte, Ilja M.;Smith, Albert Vernon;Bis, Joshua C.;Isaacs, Aaron;Newhouse, Stephen J.;Evans, Daniel S.;Post, Wendy S.;Waggott, Daryl;Lyytikainen, Leo-Pekka;Hicks, Andrew A.;Eisele, Lewin;Ellinghaus, David;Hayward, Caroline;Navarro, Pau;Ulivi, Sheila;Tanaka, Toshiko;Tester, David J.;Chatel, Stephanie;Gustafsson, Stefan;Kumari, Meena;Morris, Richard W.;Naluai, Asa T.;Padmanabhan, Sandosh;Kluttig, Alexander;Strohmer, Bernhard;Panayiotou, Andrie G.;Torres, Maria;Knoflach, Michael;Hubacek, Jaroslav A.;Slowikowski, Kamil;Raychaudhuri, Soumya;Kumar, Runjun D.;Harris, Tamara B.;Launer, Lenore J.;Shuldiner, Alan R.;Alonso, Alvaro;Bader, Joel S.;EhreT, Georg;Huang, Hailiang;Kao, W. H. Linda;Strait, James B.;Macfarlane, Peter W.;Brown, Morris;Caulfield, Mark J.;Samani, Nilesh J.;Kronenberg, Florian;Willeit, Johann;Smith, J. Gustav;Greiser, Karin H.;Schwabedissen, Henriette Meyer Zu;Werdan, Karl;Carella, Massimo;Zelante, Leopoldo;Heckbert, Susan R.;Psaty, Bruce M.;Rotter, Jerome I.;Kolcic, Ivana;Poagek, Ozren;Wright, Alan F.;Griffin, Maura;Daly, Mark J.;Arnar, David O.;Holm, Hilma;Thorsteinsdottir, Unnur;Denny, Joshua C.;Roden, Dan M.;Zuvich, Rebecca L.;Emilsson, Valur;Plump, Andrew S.;Larson, Martin G.;O'Donnell, Christopher J.;Yin, Xiaoyan;Bobboll, Marco;D'Adamo, Adamo P.;Iorio, Annamaria;Sinagra, Gianfranco;Carracedo, Angel;Cummings, Steven R.;Nalls, Michael A.;Jula, Antti;Kontula, Kimmo K.;Marjamaa, Annukka;Oikarinen, Lasse;Perola, Markus;Porthan, Kimmo;Erbe, Raimund;Hoffmann, Per;Jockel, Karl-Heinz;Kalsch, Hagen;Nothen, Markus M.;Den Hoed, Marcel;Loos, Ruth J. F.;Thelle, Dag S.;Gieger, Christian;Meitinger, Thomas;Perz, Siegfried;Peters, Annette;Pruchal, Hanna;Sinner, Moritz F.;Waldenberger, Melanie;De Boer, Rudolf A.;Franke, Lude;Van der Vleuten, Pieter A.;Beckmann, Britt Maria;Martens, Eimo;Bardail, Abdennasser;Hofman, Nynke;Wilde, Arthur A. M.;Behr, Elijah R.;Dalageorgou, Chrysoula;Giudicessi, John R.;Medeiros-Domingo, Argelia;Barc, Julien;Kyndt, Florence;Probst, Vincent;Ghidoni, Alice;Insolia, Roberto;Hamilton, Robert M.;Scherer, Stephen W.;Brandimarto, Jeffrey;Margulies, Kenneth;Moravec, Christine E.;Del Greco, Fabiola;Fuchsberger, Christian;O'Connell, Jeffrey R.;Lee, Wai K.;Watt, Graham C. M.;Campbell, Harry;Wild, Sarah H.;El Mokhtari, Nour E.;Frey, Norbert;Asselbergs, Folkert W.;Leach, Irene Mateo;Navis, Gerjan;Van den Berg, Maarten P.;Van Veldhuisen, Dirk J.;Kellis, Manolis;Krijthe, Bouwe P.;Franco, Oscar H.;Hofman, Albert;Kors, Jan A.;Uitterlinden, Andre G.;Witteman, Jacqueline C. M.;Kedenko, Lyudmyla;Lamina, Claudia;Oostra, Ben A.;Abecasis, Goncalo R.;Lakatta, Edward G.;Mulas, Antonella;Orru, Marco;Schlessinger, David;Uda, Manuela;Markus, Marcello R. P.;Volker, Uwe;Snieder, Harold;Spector, Timothy D.;Arnlov, Johan;Lind, Lars;Sundstrom, Johan;Syvanen, Ann-Christine;Kivimaki, Mika;Kahonen, Mika;Mononen, Nina;Raitakari, I. T.;Viikari, Jorma S.;Adamkova, Vera;Kiech, Stefan;Brion, Maria;Nicolaides, Andrew N.;Paulweber, Bernhard;Haerting, Johannes;Dominiczak, Anna F.;Nyberg, Fredrik;Whincup, Peter H.;Hingorani, Aroon D.;Schott, Jean-Jacques;Bezzina, Connie R.;Ingelsson, Erik;Ferrucci, Luigi;Gaspariniin, Paolo;Wilson, James F.;Rudan, Igor;Franke, Andre;Miihleisen, Thomas W.;Pramstaller, Peter P.;Lehtimaki, Terho J.;Paterson, Andrew D.;Parsa, Afshin;Liu, Yongmei;Van Duijn, Cornelia M.;Siscovick, David S.;Gudnason, Vilmundur;Jamshidi, Yalda;Salomaa, Veikko;Felix, Stephan B.;Sanna, Serena;Ritchie, Marylyn D.;Stricker, Bruno H.;Stefansson, Karl;Boyer, Laurie A.;Cappola, Thomas P.;Olsen, Jesper V.;Lage, Kasper;Schwartz, Peter J.;Kaab, Stefan;Chakravarti, Aravinda;Ackerman, Michael J.;Pfeufer, Arne;De Bakker, Paul I. W.;Newton-Cheh, Christopher
通讯作者：
Newton-Cheh, Christopher
DOI：
10.1161/circgenetics.109.895763
发表时间：
2010-06
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Smith NL;Felix JF;Morrison AC;Demissie S;Glazer NL;Loehr LR;Cupples LA;Dehghan A;Lumley T;Rosamond WD;Lieb W;Rivadeneira F;Bis JC;Folsom AR;Benjamin E;Aulchenko YS;Haritunians T;Couper D;Murabito J;Wang YA;Stricker BH;Gottdiener JS;Chang PP;Wang TJ;Rice KM;Hofman A;Heckbert SR;Fox ER;O'Donnell CJ;Uitterlinden AG;Rotter JI;Willerson JT;Levy D;van Duijn CM;Psaty BM;Witteman JC;Boerwinkle E;Vasan RS
通讯作者：
Vasan RS
影响因子：
3.7
作者：
Salfati E;Morrison AC;Boerwinkle E;Chakravarti A
通讯作者：
Chakravarti A
影响因子：
64.8
作者：
Ehret, Georg B.;Munroe, Patricia B.;Rice, Kenneth M.;Bochud, Murielle;Johnson, Andrew D.;Chasman, Daniel I.;Smith, Albert V.;Tobin, Martin D.;Verwoert, Germaine C.;Hwang, Shih-Jen;Pihur, Vasyl;Vollenweider, Peter;O'Reilly, Paul F.;Amin, Najaf;Bragg-Gresham, Jennifer L.;Teumer, Alexander;Glazer, Nicole L.;Launer, Lenore;Zhao, Jing Hua;Aulchenko, Yurii;Heath, Simon;Sober, Siim;Parsa, Afshin;Luan, Jian'an;Arora, Pankaj;Dehghan, Abbas;Zhang, Feng;Lucas, Gavin;Hicks, Andrew A.;Jackson, Anne U.;Peden, John F.;Tanaka, Toshiko;Wild, Sarah H.;Rudan, Igor;Igl, Wilmar;Milaneschi, Yuri;Parker, Alex N.;Fava, Cristiano;Chambers, John C.;Fox, Ervin R.;Kumari, Meena;Go, Min Jin;van der Harst, Pim;Kao, Wen Hong Linda;Sjogren, Marketa;Vinay, D. G.;Alexander, Myriam;Tabara, Yasuharu;Shaw-Hawkins, Sue;Whincup, Peter H.;Liu, Yongmei;Shi, Gang;Kuusisto, Johanna;Tayo, Bamidele;Seielstad, Mark;Sim, Xueling;Khanh-Dung Hoang Nguyen;Lehtimaki, Terho;Matullo, Giuseppe;Wu, Ying;Gaunt, Tom R.;Onland-Moret, N. Charlotte;Cooper, Matthew N.;Platou, Carl G. P.;Org, Elin;Hardy, Rebecca;Dahgam, Santosh;Palmen, Jutta;Vitart, Veronique;Braund, Peter S.;Kuznetsova, Tatiana;Uiterwaal, Cuno S. P. M.;Adeyemo, Adebowale;Palmas, Walter;Campbell, Harry;Ludwig, Barbara;Tomaszewski, Maciej;Tzoulaki, Ioanna;Palmer, Nicholette D.;Aspelund, Thor;Garcia, Melissa;Chang, Yen-Pei C.;O'Connell, Jeffrey R.;Steinle, Nanette I.;Grobbee, Diederick E.;Arking, Dan E.;Kardia, Sharon L.;Morrison, Alanna C.;Hernandez, Dena;Najjar, Samer;McArdle, Wendy L.;Hadley, David;Brown, Morris J.;Connell, John M.;Hingorani, Aroon D.;Day, Ian N. M.;Lawlor, Debbie A.;Beilby, John P.;Lawrence, Robert W.;Clarke, Robert;Hopewell, Jemma C.;Ongen, Halit;Dreisbach, Albert W.;Li, Yali;Young, J. Hunter;Bis, Joshua C.;Kahonen, Mika;Viikari, Jorma;Adair, Linda S.;Lee, Nanette R.;Chen, Ming-Huei;Olden, Matthias;Pattaro, Cristian;Bolton, Judith A. Hoffman;Koettgen, Anna;Bergmann, Sven;Mooser, Vincent;Chaturvedi, Nish;Frayling, Timothy M.;Islam, Muhammad;Jafar, Tazeen H.;Erdmann, Jeanette;Kulkarni, Smita R.;Bornstein, Stefan R.;Graessler, Juergen;Groop, Leif;Voight, Benjamin F.;Kettunen, Johannes;Howard, Philip;Taylor, Andrew;Guarrera, Simonetta;Ricceri, Fulvio;Emilsson, Valur;Plump, Andrew;Barroso, Ine S.;Khaw, Kay-Tee;Weder, Alan B.;Hunt, Steven C.;Sun, Yan V.;Bergman, Richard N.;Collins, Francis S.;Bonnycastle, Lori L.;Scott, Laura J.;Stringham, Heather M.;Peltonen, Leena;Perola, Markus;Vartiainen, Erkki;Brand, Stefan-Martin;Staessen, Jan A.;Wang, Thomas J.;Burton, Paul R.;Artigas, Maria Soler;Dong, Yanbin;Snieder, Harold;Wang, Xiaoling;Zhu, Haidong;Lohman, Kurt K.;Rudock, Megan E.;Heckbert, Susan R.;Smith, Nicholas L.;Wiggins, Kerri L.;Doumatey, Ayo;Shriner, Daniel;Veldre, Gudrun;Viigimaa, Margus;Kinra, Sanjay;Prabhakaran, Dorairaj;Tripathy, Vikal;Langefeld, Carl D.;Rosengren, Annika;Thelle, Dag S.;Corsi, Anna Maria;Singleton, Andrew;Forrester, Terrence;Hilton, Gina;McKenzie, Colin A.;Salako, Tunde;Iwai, Naoharu;Kita, Yoshikuni;Ogihara, Toshio;Ohkubo, Takayoshi;Okamura, Tomonori;Ueshima, Hirotsugu;Umemura, Satoshi;Eyheramendy, Susana;Meitinger, Thomas;Wichmann, H. -Erich;Cho, Yoon Shin;Kim, Hyung-Lae;Lee, Jong-Young;Scott, James;Sehmi, Joban S.;Zhang, Weihua;Hedblad, Bo;Nilsson, Peter;Smith, George Davey;Wong, Andrew;Narisu, Narisu;Stancakova, Alena;Raffel, Leslie J.;Yao, Jie;Kathiresan, Sekar;O'Donnell, Christopher J.;Schwartz, Stephen M.;Ikram, M. Arfan;Longstreth, W. T., Jr.;Mosley, Thomas H.;Seshadri, Sudha;Shrine, Nick R. G.;Wain, Louise V.;Morken, Mario A.;Swift, Amy J.;Laitinen, Jaana;Prokopenko, Inga;Zitting, Paavo;Cooper, Jackie A.;Humphries, Steve E.;Danesh, John;Rasheed, Asif;Goel, Anuj;Hamsten, Anders;Watkins, Hugh;Bakker, Stephan J. L.;van Gilst, Wiek H.;Janipalli, Charles S.;Mani, K. Radha;Yajnik, Chittaranjan S.;Hofman, Albert;Mattace-Raso, Francesco U. S.;Oostra, Ben A.;Demirkan, Ayse;Isaacs, Aaron;Rivadeneira, Fernando;Lakatta, Edward G.;Orru, Marco;Scuteri, Angelo;Ala-Korpela, Mika;Kangas, Antti J.;Lyytikainen, Leo-Pekka;Soininen, Pasi;Tukiainen, Taru;Wurtz, Peter;Ong, Rick Twee-Hee;Doerr, Marcus;Kroemer, Heyo K.;Voelker, Uwe;Voelzke, Henry;Galan, Pilar;Hercberg, Serge;Lathrop, Mark;Zelenika, Diana;Deloukas, Panos;Mangino, Massimo;Spector, Tim D.;Zhai, Guangju;Meschia, James F.;Nalls, Michael A.;Sharma, Pankaj;Terzic, Janos;Kumar, M. V. Kranthi;Denniff, Matthew;Zukowska-Szczechowska, Ewa;Wagenknecht, Lynne E.;Fowkes, F. Gerald R.;Charchar, Fadi J.;Schwarz, Peter E. H.;Hayward, Caroline;Guo, Xiuqing;Rotimi, Charles;Bots, Michiel L.;Brand, Eva;Samani, Nilesh J.;Polasek, Ozren;Talmud, Philippa J.;Nyberg, Fredrik;Kuh, Diana;Laan, Maris;Hveem, Kristian;Palmer, Lyle J.;van der Schouw, Yvonne T.;Casas, Juan P.;Mohlke, Karen L.;Vineis, Paolo;Raitakari, Olli;Ganesh, Santhi K.;Wong, Tien Y.;Tai, E. Shyong;Cooper, Richard S.;Laakso, Markku;Rao, Dabeeru C.;Harris, Tamara B.;Morris, Richard W.;Dominiczak, Anna F.;Kivimaki, Mika;Marmot, Michael G.;Miki, Tetsuro;Saleheen, Danish;Chandak, Giriraj R.;Coresh, Josef;Navis, Gerjan;Salomaa, Veikko;Han, Bok-Ghee;Zhu, Xiaofeng;Kooner, Jaspal S.;Melander, Olle;Ridker, Paul M.;Bandinelli, Stefania;Gyllensten, Ulf B.;Wright, Alan F.;Wilson, James F.;Ferrucci, Luigi;Farrall, Martin;Tuomilehto, Jaakko;Pramstaller, Peter P.;Elosua, Roberto;Soranzo, Nicole;Sijbrands, Eric J. G.;Altshuler, David;Loos, Ruth J. F.;Shuldiner, Alan R.;Gieger, Christian;Meneton, Pierre;Uitterlinden, Andre G.;Wareham, Nicholas J.;Gudnason, Vilmundur;Rotter, Jerome I.;Rettig, Rainer;Uda, Manuela;Strachan, David P.;Witteman, Jacqueline C. M.;Hartikainen, Anna-Liisa;Beckmann, Jacques S.;Boerwinkle, Eric;Vasan, Ramachandran S.;Boehnke, Michael;Larson, Martin G.;Jarvelin, Marjo-Riitta;Psaty, Bruce M.;Abecasis, Goncalo R.;Chakravarti, Aravinda;Elliott, Paul;van Duijn, Cornelia M.;Newton-Cheh, Christopher;Levy, Daniel;Caulfield, Mark J.;Johnson, Toby
通讯作者：
Johnson, Toby
影响因子：
37.8
作者：
Smith NL;Chen MH;Dehghan A;Strachan DP;Basu S;Soranzo N;Hayward C;Rudan I;Sabater-Lleal M;Bis JC;de Maat MP;Rumley A;Kong X;Yang Q;Williams FM;Vitart V;Campbell H;Mälarstig A;Wiggins KL;Van Duijn CM;McArdle WL;Pankow JS;Johnson AD;Silveira A;McKnight B;Uitterlinden AG;Wellcome Trust Case Control Consortium;;Aleksic N;Meigs JB;Peters A;Koenig W;Cushman M;Kathiresan S;Rotter JI;Bovill EG;Hofman A;Boerwinkle E;Tofler GH;Peden JF;Psaty BM;Leebeek F;Folsom AR;Larson MG;Spector TD;Wright AF;Wilson JF;Hamsten A;Lumley T;Witteman JC;Tang W;O'Donnell CJ
通讯作者：
O'Donnell CJ