The influence of maternal weight and glucose tolerance on infant birthweight in Latino mother-infant pairs
The influence of maternal weight and glucose tolerance on infant birthweight in Latino mother-infant pairs
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DOI：
10.2105/ajph.2005.065953
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发表时间：
2006-12-01
影响因子：
12.7
通讯作者：
Herman, William H.
中科院分区：
文献类型：
--
作者：
Kieffer, Edith C.;Tabaei, Bahman P.;Herman, William H.
目标。我们评估了母亲人体测量和代谢变量（包括葡萄糖耐量）对婴儿出生体重的影响。方法。在我们对 1041 对拉丁裔母婴进行的前瞻性、基于人群的队列研究中，我们使用了标准化访谈、人体测量、代谢测定和病历审查。我们通过方差分析以及双变量和多元线性回归分析评估了母亲社会人口统计学、产前护理、人体测量和代谢特征与出生体重之间的关系。结果。在这项研究中，42% 的女性在怀孕时体重超重或肥胖；至少 36% 的体重增加超过了建议值。 27% 的女性至少有一定程度的血糖异常，其中 6.8% 患有妊娠糖尿病。母亲多胎数、身高、体重、体重增加和 1 小时筛查血糖水平是调整胎龄后婴儿出生体重的显着独立预测因素。结论。出生体重的研究应考虑母亲的血糖水平。鉴于与母亲体重过重、体重增加和葡萄糖不耐受相关的母婴不良结局风险增加，以及这些疾病和 2 型糖尿病在拉丁裔中的高患病率，公共卫生专业人员拥有通过产前和产后干预进行预防的独特机会。
Objectives. We assessed the influence of maternal anthropometric and metabolic variables, including glucose tolerance, on infant birthweight.Methods. In our prospective, population-based cohort study of 1041 Latino mother-infant pairs, we used standardized interviews, anthropometry, metabolic assays, and medical record reviews. We assessed relationships among maternal sociodemographic, prenatal care, anthropometric, and metabolic characteristics and birthweight with analysis of variance and bivariate and multivariate linear regression analyses.Results. Forty-two percent of women in this study entered pregnancy overweight or obese; at least 36% exceeded weight-gain recommendations. Twenty-seven percent of the women had at least some degree of glucose abnormality, including 6.8% who had gestational diabetes. Maternal multiparity, height, weight, weight gain, and 1-hour screening glucose levels were significant independent predictors of infant birthweight after adjustment for gestational age.Conclusion. Studies of birthweight should account for maternal glucose level. Given the increased risk of adverse maternal and infant outcomes associated with excessive maternal weight, weight gain, and glucose intolerance, and the high prevalence of these conditions and type 2 diabetes among Latinas, public health professionals have unique opportunities for prevention through prenatal and postpartum interventions.