Plasma drug and homovanillic acid levels in psychotic patients receiving neuroleptics.
Plasma drug and homovanillic acid levels in psychotic patients receiving neuroleptics.
复制标题
接受精神安定药的精神病患者的血浆药物和高香草酸水平。
作者：
P. Q. Harris;S. J. Brown;M. Friedman;N. Bacopoulos
报道了一组精神病受试者的血浆抗神经药和高香草酸(HVA)水平，这些受试者在抗精神病药物治疗后表现出临床改善。临床上有效的血浆抗神经药水平，通过放射受体测定并以母药纳摩尔浓度或氟哌啶醇等效物表示，对于所测试的七种抗神经药是不同的。血浆HVA用高压液相色谱-电化学检测法(LCEC)测定，在开始抗精神病药物治疗时升高，在停用抗精神病药物时下降。血浆抗精神病药水平与HVA水平、HVA水平与临床疗效均无相关性。用母药纳摩尔浓度表示的平均治疗性血浆抗神经药浓度，与同一药物取代大鼠纹状体膜D-1和D-2受体上的~3H-多巴胺的能力相关。这是第一份报告，临床测量的血浆浓度高到足以取代中枢神经系统中多巴胺的特定受体。
Plasma neuroleptic and homovanillic acid (HVA) levels are reported for a group of psychotic subjects exhibiting clinical improvement in response to neuroleptic medication. Clinically effective plasma neuroleptic levels, measured by a radioreceptor assay and expressed as either nanomolar concentration of parent drug or as haloperidol equivalents, were different for the seven neuroleptics tested. Plasma HVA, measured by high-pressure liquid chromatography with electrochemical detection (LCEC), increased in response to initiation of neuroleptic treatment and decreased when neuroleptic medication was withdrawn. No correlations were found between plasma neuroleptic level and HVA level or between HVA level and clinical response. Mean therapeutic plasma levels of neuroleptics, expressed as nanomolar concentration of parent drug, correlated with the potencies of the same drug in displacing 3H-dopamine from D-1 and D-2 receptors in rat striatal membranes. This represents the first report that clinically measured plasma concentrations are high enough to displace dopamine from its specific receptors in the CNS.