Alteration in Cellular Signaling and Metabolic Reprogramming during Viral Infection.
Alteration in Cellular Signaling and Metabolic Reprogramming during Viral Infection.
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DOI：
10.1128/mbio.00635-21
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发表时间：
2021-10-26
期刊：
影响因子：
6.4
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Pant A;Dsouza L;Yang Z
细胞活动受到众多信号通路的精细调节，以支持复杂生命过程的特定功能。病毒是专性细胞内寄生虫。病毒复制的每一步最终都由病毒与其宿主细胞的相互作用控制。由于病毒复制的需要，病毒感染细胞的营养需求与未感染细胞不同。为了提高生存和复制的机会，病毒已经进化到可以控制细胞过程，包括细胞新陈代谢，增强这些过程来满足它们的需求。本文总结了有关病毒诱导的主要细胞代谢途径改变的最新发现，重点关注病毒如何调节各种信号级联以诱导这些变化。我们首先概述信号通路在细胞代谢中所起的作用。然后我们讨论不同的病毒如何针对这些信号通路来重新编程宿主代谢以满足病毒的需求。我们强调了理解代谢相关的病毒-宿主相互作用方面的差距，并讨论了研究这些变化将如何增强我们对代谢调节所涉及的基本过程的理解。最后，我们讨论了利用这些过程来对抗病毒性疾病以及其他疾病（包括代谢紊乱和癌症）的潜力。
Cellular activities are finely regulated by numerous signaling pathways to support specific functions of complex life processes. Viruses are obligate intracellular parasites. Each step of viral replication is ultimately governed by the interaction of a virus with its host cells. Because of the demands of viral replication, the nutritional needs of virus-infected cells differ from those of uninfected cells. To improve their chances of survival and replication, viruses have evolved to commandeer cellular processes, including cell metabolism, augmenting these processes to support their needs. This article summarizes recent findings regarding virus-induced alterations to major cellular metabolic pathways focusing on how viruses modulate various signaling cascades to induce these changes. We begin with a general introduction describing the role played by signaling pathways in cellular metabolism. We then discuss how different viruses target these signaling pathways to reprogram host metabolism to favor the viral needs. We highlight the gaps in understanding metabolism-related virus-host interactions and discuss how studying these changes will enhance our understanding of fundamental processes involved in metabolic regulation. Finally, we discuss the potential to harness these processes to combat viral diseases, as well as other diseases, including metabolic disorders and cancers.