Aseptic meningitis due to administration of intravenous immunoglobulin with an unusually high number of leukocytes in cerebrospinal fluid
Aseptic meningitis due to administration of intravenous immunoglobulin with an unusually high number of leukocytes in cerebrospinal fluid
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DOI：
10.1097/00006565-200212000-00006
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发表时间：
2002-12-01
影响因子：
1.4
通讯作者：
García-Martín, FJ
中科院分区：
文献类型：
--
作者：
Obando, I;Durán, I;García-Martín, FJ
据报道，在接受静脉注射免疫球蛋白（IVIG）治疗的儿童中，神经系统不良反应高达34%(1)。反应通常是轻微和短暂的，但少数患者发展为无菌性脑膜炎（AM）。临床和脑脊液（CSF）特征可能与细菌性脑膜炎患者的特征难以区分，这在某些情况下构成了急诊科诊断和患者管理的挑战(2)。我们描述了两例患者的免疫性血小板减少性紫癜（ITP）谁发展AM后，输注IVIG。其中一人脑脊液中白细胞异常增多。我们还回顾了先前报道的ivig相关AM的儿科病例。
Neurologic adverse reactions have been reported in up to 34% children who are treated with intravenous immunoglobulin (IVIG) (1). Reactions are generally mild and transient, but a small number of patients develop aseptic meningitis (AM). Clinical and cerebrospinal fluid (CSF) characteristics may be indistinguishable from those found in patients with bacterial meningitis, which constitutes in some instances a diagnostic and patient management challenge in the emergency department setting (2).We describe two patients with immune thrombocytopenic purpura (ITP) who developed AM subsequent to the infusion of IVIG. One of them presented with an unusually high number of leukocytes in CSF. We also review previously reported pediatric cases of IVIG-associated AM.