Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex
Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex
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DOI：
10.1016/j.antiviral.2003.08.017
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发表时间：
2003-10-01
影响因子：
7.6
通讯作者：
Bienz, K
中科院分区：
文献类型：
--
作者：
Moradpour, D;Gosert, R;Bienz, K
丙型肝炎病毒（HCV）在由病毒蛋白、复制RNA和改变的细胞膜组成的膜相关复合物中复制其基因组。HCV非结构蛋白参与基因组复制的膜结合的决定因素已经确定。此外，一个特定的膜改变，指定的膜网，最近被确定为病毒RNA合成的网站，因此，代表HCV复制复合物。这些发现增加了我们目前对HCV生命周期的理解，并可能最终允许设计针对丙型肝炎的新的抗病毒策略。(C)2003 Elsevier B.V.保留所有权利。
Hepatitis C virus (HCV) replicates its genome in a membrane-associated complex composed of viral proteins, replicating RNA, and altered cellular membranes. Determinants for membrane association of the HCV nonstructural proteins involved in genome replication have been defined. In addition, a specific membrane alteration, designated membranous web, was recently identified as the site of viral RNA synthesis and, therefore, represents the HCV replication complex. These findings add to our current understanding of the HCV life cycle and may ultimately allow to design novel antiviral strategies against hepatitis C. (C) 2003 Elsevier B.V. All rights reserved.