Synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction using organocatalysts
Synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction using organocatalysts
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DOI：
10.1016/j.tet.2006.12.074
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发表时间：
2007-02-26
期刊：
影响因子：
2.1
通讯作者：
Maurya, Ram Awatar
中科院分区：
文献类型：
--
作者：
Kumar, Atul;Maurya, Ram Awatar
报道了一种新的、绿色的、室温下利用有机催化剂通过不对称Hantzsch反应快速合成多氢喹啉衍生物的方法。该方法是合成多氢喹啉衍生物的一种简单、环境友好、快速、高产率的反应。研究了L-脯氨酸、反式-4-羟基-L-脯氨酸、L-硫代脯氨酸、DL-苯甘氨酸和（-）-辛可尼定等小分子有机催化剂在水溶液、有机溶剂和无溶剂条件下的催化效率。(c)2007爱思唯尔有限公司版权所有。
A novel and green approach for efficient and rapid synthesis of polyhydroquinoline derivatives via unsymmietnc Hantzsch reaction using organocatalysts at room temperature was reported. The process is a simple, environmentally friendly, rapid, and high yielding reaction for the synthesis of polyhydroquinoline derivatives. The catalytic efficiency of various small organocatalysts such as L-proline, trans-4-hydroxy-L-proline, L-thiaproline, DL-phenylglycine, and (-)-cinchonidine was studied under aqueous, organic, and solvent free conditions. (c) 2007 Elsevier Ltd. All rights reserved.