Is hypertension an inflammatory disease?
Is hypertension an inflammatory disease?
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DOI：
10.1016/j.mehy.2004.06.017
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发表时间：
2005-01-01
影响因子：
4.7
通讯作者：
Hui, RT
中科院分区：
文献类型：
--
作者：
Li, JJ;Fang, CH;Hui, RT
高血压被认为是一种多因素的特征，是环境和遗传因素共同作用的结果，包括过量的饮食盐或酒精摄入、压力、年龄、遗传和家族史、肥胖、缺乏运动以及高饱和脂肪饮食。然而，在过去的几年中，收集了大量关于血管炎症的信息，表明炎症可能参与了高血压的发生和发展，并使我们重新思考高血压的发病机制。动物模型和患者的证据表明，高血压作为冠心病的主要危险因素，已被认为通过增加几种介质的表达来发挥促炎作用，这些介质包括白细胞黏附分子、趋化因子、特异性生长因子、热休克蛋白、内皮素-1和血管紧张素。炎症和高血压之间的关联也让人想起了低度炎症和代谢综合征的其他组成部分与高血压患者的内皮功能障碍和血清C反应蛋白水平升高之间的类似关联。高血压是一种炎症性疾病吗？这个问题刺激了关于血管炎症在高血压中的作用的研究。因此，深入了解高血压的炎症机制，有助于寻找新的治疗策略，降低高血压的发病率和病死率，减轻高血压靶器官的损害。(C)2004爱思唯尔有限公司。保留所有权利。
Hypertension has been recognized as a multi-factorial trait resulting from the effect of a combination of environmental and genetic factors, including excess dietary salt or alcohol intake, stress, age, genetics and family history, obesity, physical inactivity, as well as high saturated fat diet. During the past few years, however, a large amount of information has been collected on the vascular inflammation, indicating that inflammation may involve in the initiation as well as development of hypertension and allowing us to reconsidering the pathogenic mechanisms of hypertension.Evidence from animal models as well as patients, have indicated that hypertension, an established major risk factor for coronary artery disease, has been suggested to exert pro-inflammatory actions through the increased expression of several mediators, including leukocyte adhesion molecules, chemokines, specific growth factors, heat shock proteins, endothelin-1, and angiotensin. The association between inflammation and hypertension recalls also a similar association between low-grade inflammation and other components of the metabolic syndrome, and endothelial dysfunction as well as increased serum levels of C-reactive protein in patients with hypertension.Is hypertension an inflammatory disease? This question has stimulated research on the role of vascular inflammation in hypertension. A better understanding of the inflammatory mechanism in hypertension may, therefore, contribute to novel therapeutic strategies to decrease the morbidity as well as mortality of hypertension, and alleviated hypertensive target organ damage. (C) 2004 Elsevier Ltd. All rights reserved.