Prevention of Lactogenic Toxocara cati Infections in Kittens by Application of an Emodepside/Praziquantel Spot-on (Profender®) to the Pregnant Queen
Prevention of Lactogenic Toxocara cati Infections in Kittens by Application of an Emodepside/Praziquantel Spot-on (Profender®) to the Pregnant Queen
复制标题
DOI：
10.1007/s00436-015-4523-y
复制
发表时间：
2015-08-01
影响因子：
2
通讯作者：
Strube, Christina
中科院分区：
文献类型：
--
作者：
Boehm, Claudia;Petry, Gabriele;Strube, Christina
本研究旨在评价emodepside 2.1%（w/v）/praziquantel 8.6%（w/v）局部溶液（猫用Profender（R）滴剂）预防催乳弓蛔虫感染的功效。对两组8只确认妊娠的猫进行对照试验。所有猫均以每日2000 T的剂量感染。从受孕后50天开始，连续10天将猫卵接种到子宫中，以产生急性感染。在受孕后60天进行处理。在治疗组中的女王接受了最小治疗剂量（3毫克/公斤的emodepside和12毫克/公斤的吡喹酮）的emodepside/吡喹酮解决方案，而对照组用安慰剂spot-on. Efficiency进行了评价产后56天的每窝随机选择一只小猫尸检和研究组之间的蠕虫负担的比较。此外，剩余幼猫和所有蚁后驱虫后随粪便排出的蠕虫定量支持尸检结果。妊娠晚期治疗的有效率为98.7%（p < 0.0001）。所有尸检对照小猫均感染（几何平均值30.6）。治疗组8只幼猫中有7只无T。cati（几何平均值0.4）。驱虫后的蠕虫计数反映了尸检时获得的结果。未观察到治疗的副作用。结论：在妊娠晚期使用依莫地塞/吡喹酮滴眼液治疗可有效防止T。猫的后代。研究设计有助于生成可靠的数据，同时处死的动物数量最少。
This study aimed to evaluate the efficacy of an emodepside 2.1 % (w/v)/praziquantel 8.6 % (w/v) topical solution (Profender (R) spot-on for cats) in the prevention of lactogenic Toxocara cati infections. A controlled test was performed with two groups of 8 cats with confirmed pregnancy. All cats were infected with daily doses of 2000 T. cati eggs for 10 consecutive days starting 50 days post conception to produce an acute infection. Treatment was performed 60 days post conception. Queens in the treatment group received the emodepside/praziquantel solution at the minimum therapeutic dose (3 mg/kg emodepside and 12 mg/kg praziquantel), while the control group was treated with a placebo spot-on. Efficacy was evaluated 56 days post partum by necropsy of one randomly selected kitten of each litter and comparison of the worm burdens between the study groups. Additionally the necropsy results were supported by quantification of worms expelled with the faeces after deworming of the remaining kittens and all queens. The treatment in late pregnancy resulted in an efficacy of 98.7 % (p < 0.0001). All necropsied control kittens were infected (geometric mean 30.6). Seven of 8 kittens from treated mothers were free of T. cati (geometric mean 0.4). Worm counts after deworming reflected the results obtained at necropsy. No side effects of the treatment were observed. It is concluded that treatment with an emodepside/praziquantel spot-on solution during late pregnancy effectively prevents lactogenic transmission of T. cati to the offspring. The study design facilitated the generation of reliable data, while at the same time a minimum number of animals was sacrificed.