Oral contraceptive use and the risk of myocardial infarction.
Oral contraceptive use and the risk of myocardial infarction.
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口服避孕药的使用和心肌梗塞的风险。
DOI：
10.1093/oxfordjournals.aje.a115592
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发表时间：
1990
影响因子：
5
通讯作者：
Shapiro,S
中科院分区：
文献类型：
--
作者：
Rosenberg,L;Palmer,JR;Lesko,SM;Shapiro,S
1985年至1988年在新英格兰进行的一项以医院为基础的病例对照研究评估了口服避孕药使用与心肌梗死风险的关系; 910名首次心肌梗死的妇女与1,760名对照妇女进行了比较。口服避孕药的使用，停药后，与心肌梗死的风险增加无关，无论是在很久以前或最近停止使用。在考虑混杂因素后，过去使用口服避孕药至少5年的妇女与未使用者相比的总体相对风险估计值为1.1（95%置信区间0.8-1.5）。在任何年龄组、有诱发因素的妇女亚组或因无诱发因素而处于低风险的妇女中，既往使用与风险无关。研究结果表明，长期口服避孕药，停药后，不影响心肌梗死的风险。目前使用者很少，目前使用的结果是不确定的：对于在前一个月使用口服避孕药的绝经前妇女，相对于那些没有使用口服避孕药的妇女，年龄调整的相对风险估计为1.1（95%置信区间0.4-3.1）。
The relation of oral contraceptive use to the risk of myocardial infarction was assessed in a hospital-based case-control study of women aged 25–64 years conducted from 1985 to 1988 in New England; 910 women with first myocardial infarctions were compared with 1,760 control women. Oral contraceptive use, after discontinuation, was not associated with an increased risk of myocardial infarction, whether use had ceased in the distant past or more recently. The overall relative risk estimate for women who had used oral contraceptives in the past for at least 5 years compared with nonusers was 1.1 (95% confidence interval 0.8–1.5) after allowance for confounding factors. Past use was not associated with risk in any age group, in subgroups of women with predisposing factors, or in women at low risk because of the absence of predisposing factors. The results suggest that long-term oral contraceptive use, after discontinuation, does not influence the risk of myocardial infarction. There were few current users and the results for current use were inconclusive: for premenopausal women who had used oral contraceptives in the previous month relative to those who had not, the age-adjusted relative risk estimate was 1.1 (95% confidence interval 0.4–3.1).