TRANSFORMATION OF ESTABLISHED MURINE FIBROBLASTS WITH AN ACTIVATED CELLULAR HARVEY-RAS ONCOGENE OR THE POLYOMA-VIRUS MIDDLE T-GENE INCREASES CELL PERMISSIVENESS TO PARVOVIRUS MINUTE-VIRUS-OF-MICE
TRANSFORMATION OF ESTABLISHED MURINE FIBROBLASTS WITH AN ACTIVATED CELLULAR HARVEY-RAS ONCOGENE OR THE POLYOMA-VIRUS MIDDLE T-GENE INCREASES CELL PERMISSIVENESS TO PARVOVIRUS MINUTE-VIRUS-OF-MICE
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DOI：
10.1016/s0300-9084(86)81058-6
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发表时间：
1986-07-01
期刊：
影响因子：
3.9
通讯作者：
ROMMELAERE, J
中科院分区：
文献类型：
--
作者：
MOUSSET, S;CORNELIS, J;ROMMELAERE, J
用多瘤病毒中T基因或激活的人哈维-ras癌基因转化永久性啮齿动物成纤维细胞，可增加细胞对小鼠自主细小病毒分钟病毒的容纳性。细小病毒DNA扩增在未转化的亲本细胞系中受到限制。对细小病毒生命周期各种参数的分析表明，在转化的细胞系中，这一障碍被部分克服。
Transformation of permanent rodent fibroblast cells by the polyoma virus middle T gene or the activated human Harvey-ras oncogene results in increased cellular permissiveness to the autonomous parvovirus minute-virus-of-mice. Parvoviral DNA amplification is restricted in the untransformed parental cell lines. Analysis of various parameters of the parvoviral life cycle shows that this block is partially overcome in the transformed lines.